{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:21:50Z","timestamp":1777724510951,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>The pathogenesis of Sj\u00f6gren's syndrome (SS) is poorly understood. In this study we used an in-house mouse spleen cDNA microarray to analyse genes in spleens from MRL\/lpr (an SS mouse model) mice. We have previously demonstrated that GRAP genes were up-regulated in salivary glands of the same mice. The microarray analysis showed that seven out of 2304 genes were highly expressed in spleens from the MRL\/ lpr mice, one of which was the GRAP gene. In other words, the GRAP gene is highly expressed in the salivary glands and spleen of MRL\/lpr mice. We also carried out immunohistochemical studies. Mouse and human Grb-2-related adaptor protein ( GRAP) antigens were expressed on ductal cells and infiltrating lymphocytes in salivary glands of MRL \/lpr mice and SS patients, but only weakly in controls (MRL\/+ mice and individuals with salivary cysts). These results suggest that the GRAP gene might have a role in the pathogenesis of SS.<\/jats:p>","DOI":"10.1177\/147323000403200308","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:28Z","timestamp":1361974948000},"page":"284-291","source":"Crossref","is-referenced-by-count":1,"title":["Detection of Grb-2-related Adaptor Protein Gene (\n                    <i>GRAP<\/i>\n                    ) and Peptide Molecule in Salivary Glands of MRL\/\n                    <i>lpr<\/i>\n                    Mice and Patients with Sj\u00f6gren's Syndrome"],"prefix":"10.1177","volume":"32","author":[{"given":"H","family":"Shiraiwa","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan"},{"name":"Department of Internal Medicine, Nerima Hikarigaoka Nihon University Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Takei","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Discovery Technology Laboratory, Research and Development Division, Mitsubishi Pharma Corp., Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Azuma","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics, Chiba University, Graduate School of Medicine, Chiba, 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