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Ninety-nine patients in the multicentre, randomized, double-blind study took metformin (1500 mg\/day) plus glimepiride (2 mg\/day) or rosiglitazone (4 mg\/day) for 12 months. Changes in body mass index, glycosylated haemoglobin (HbA\n                    <jats:sub>1c<\/jats:sub>\n                    ), Lp(a) and HCT were primary efficacy variables. Fasting plasma glucose (FPG), post-prandial plasma glucose (PPG) and homeostasis model assessment index were also used to assess efficacy. On average, HbA\n                    <jats:sub>1c<\/jats:sub>\n                    decreased by 9.1% and 8.1%, FPG decreased by 7.3% and 10.9%, and PPG decreased by 7.6% and 10.5%, respectively, in the glimepiride and rosiglitazone groups after 12 months. Patients receiving rosiglitazone experienced more rapid improvement in glycaemic control than those on glimepiride, and showed a significant improvement in insulin resistance-related parameters. There was a statistically significant decrease in basal homocysteinaemia in glimepiride-treated patients (\u221227.3%), but not in rosiglitazone-treated patients. Rosiglitazone plus metformin significantly improved long-term control of insulin resistance-related parameters compared with glimepiride plus metformin, although glimepiride treatment was associated with a slight improvement in cholesterolaemia, not observed in the rosiglitazone-treated patients, and with significant improvements in non-traditional risk factors for cardiovascular disease, such as basal homocysteinaemia and plasma Lp(a) levels.\n                  <\/jats:p>","DOI":"10.1177\/147323000503300303","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"284-294","source":"Crossref","is-referenced-by-count":17,"title":["Long-term Effect of Glimepiride and Rosiglitazone on Non-conventional Cardiovascular Risk Factors in Metformin-treated Patients Affected by Metabolic Syndrome: A Randomized, Double-blind Clinical Trial"],"prefix":"10.1177","volume":"33","author":[{"given":"G","family":"Derosa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AV","family":"Gaddi","sequence":"additional","affiliation":[{"name":"\u2018G. Descovich\u2019 Atherosclerosis Study Centre, \u2018D. Campanacci\u2019 Department of Clinical Medicine and Applied Biotechnology, University of Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Ciccarelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Fogari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ghelfi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AFG","family":"Cicero","sequence":"additional","affiliation":[{"name":"\u2018G. 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