{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:23:51Z","timestamp":1777724631681,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p>Alginate-based reflux suppressant preparations provide symptom relief by forming a physical barrier on top of the stomach contents in the form of a neutral floating gel or raft. This study investigated whether reduced acidity in the stomach brought about by omeprazole pre-treatment affected the formation and gastric residence time of alginate rafts. It was a balanced, cross-over study in 12 healthy non-patient volunteers following a single dose of two indium-111-labelled alginate tablets in the presence or absence of 3 days' pre-treatment with omeprazole. Raft formation and gastric residence, in the presence of a technetium-99m-labelled meal, were assessed by gamma scintigraphy for 3 h after alginate tablet administration. The relative raft-forming ability of alginate tablets after omeprazole compared with alginate tablets alone was 0.950 with 95% confidence intervals of 0.882 and 1.018. Pre-treatment and co-administration with omeprazole has no significant effect on the raft-forming ability of alginate tablets.<\/jats:p>","DOI":"10.1177\/147323000503300305","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"301-308","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Omeprazole Pre-treatment on Rafts Formed by Reflux Suppressant Tablets Containing Alginate"],"prefix":"10.1177","volume":"33","author":[{"given":"PW","family":"Dettmar","sequence":"first","affiliation":[{"name":"Reckitt Benckiser Healthcare (UK) Ltd, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SL","family":"Little","sequence":"additional","affiliation":[{"name":"Reckitt Benckiser Healthcare (UK) Ltd, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Baxter","sequence":"additional","affiliation":[{"name":"Reckitt Benckiser Healthcare (UK) Ltd, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,5,1]]},"reference":[{"key":"bibr1-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(86)90238-3"},{"key":"bibr2-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(84)90192-3"},{"key":"bibr3-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(84)90159-5"},{"key":"bibr4-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(87)90212-2"},{"key":"bibr5-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1038\/290159a0"},{"key":"bibr6-147323000503300305","first-page":"563","volume":"15","author":"Knight LC","year":"1988","journal-title":"Nucl Med Biol"},{"key":"bibr7-147323000503300305","first-page":"123","volume":"8","author":"Washington N","year":"1998","journal-title":"STP Pharma Sci"},{"key":"bibr8-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1990.tb00509.x"},{"key":"bibr9-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1993.tb00132.x"},{"key":"bibr10-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(84)90085-4"},{"key":"bibr11-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-55-655-533"},{"key":"bibr12-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198308000-00006"},{"key":"bibr13-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-198504000-00005"},{"key":"bibr14-147323000503300305","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1979.tb05903.x"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000503300305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000503300305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:23Z","timestamp":1777459223000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000503300305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1177\/147323000503300305"],"URL":"https:\/\/doi.org\/10.1177\/147323000503300305","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}