{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:24:03Z","timestamp":1777724643470,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p>We studied the effect of hydroxyethyl starch (HES) on intestinal production of cytokines and activation of transcription factors in sepsis. Septic rats, induced by intraperitoneal lipopolysaccharide (LPS) (5 mg\/kg), were treated with intravenous HES (16 ml\/kg) or saline (64 ml\/kg). Rat ileal tissues were collected at 2 h, 3 h or 6 h after LPS challenge. Levels of tumour necrosis factor alpha (TNF-\u03b1), interleukin (IL) 1\u03b2, IL-6, IL-8 and IL-10, cytokine mRNAs, activities of nuclear factor kappa-B (NF-\u03baB) and activator protein-1 (AP-1), and the number of ileal myeloperoxidase (MPO)-positive cells were determined for each group. HES significantly reduced the LPS-induced increase in intestinal levels of TNF-\u03b1, IL-1\u03b2, IL-6, IL-8 and their corresponding mRNAs. HES also decreased the number of MPO-positive cells induced by LPS and inhibited activation of NF-\u03baB and AP-1. The results suggest that in sepsis, HES may down-regulate intestinal pro-inflammatory cytokine production via suppression of NF-\u03baB and AP-1 activation.<\/jats:p>","DOI":"10.1177\/147323000503300403","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"379-388","source":"Crossref","is-referenced-by-count":3,"title":["Hydroxyethyl Starch Inhibits Intestinal Production of Cytokines and Activation of Transcription Factors in Endotoxaemic Rats"],"prefix":"10.1177","volume":"33","author":[{"given":"R","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-J","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-G","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,7,1]]},"reference":[{"key":"bibr1-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91728-4"},{"key":"bibr2-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.333"},{"key":"bibr3-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1186\/cc965"},{"key":"bibr4-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.4.599"},{"key":"bibr5-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39399219286.x"},{"key":"bibr6-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1007\/BF02425053"},{"key":"bibr7-147323000503300403","first-page":"451","volume":"33","author":"Tian J","year":"2003","journal-title":"Ann Clin Lab Sci"},{"key":"bibr8-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000099720.25581.86"},{"key":"bibr9-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199501000-00012"},{"key":"bibr10-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<343::AID-PATH522>3.0.CO;2-M"},{"key":"bibr11-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302942200"},{"key":"bibr12-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1997.01430280038005"},{"key":"bibr13-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1998.5385"},{"key":"bibr14-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.9.2218"},{"key":"bibr15-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199505000-00006"},{"key":"bibr16-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5339.866"},{"key":"bibr17-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703055"},{"key":"bibr18-147323000503300403","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2002.01453.x"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000503300403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000503300403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:25Z","timestamp":1777459225000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000503300403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1177\/147323000503300403"],"URL":"https:\/\/doi.org\/10.1177\/147323000503300403","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}