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Sixty consecutive male patients (mean age 22 \u00b1 3 years) with isolated chronic aortic regurgitation were enrolled in the study together with a control group of 30 age-matched healthy volunteers (group A). Patients were classified with regard to aortic regurgitation vena contracta width as follows: group B, &lt; 3 mm, mild ( n = 16); group C, \u2265 3 and &lt; 6 mm, moderate ( n = 26); group D, \u2265 6 mm, severe ( n = 18). BNP measurements were performed with a fluorescence immunoassay kit. BNP levels were increased in patients with aortic regurgitation, and severity of regurgitation had a significant influence on BNP levels. This effect can be explained by the volume loading effect of aortic regurgitation.<\/jats:p>","DOI":"10.1177\/147323000503300411","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"454-459","source":"Crossref","is-referenced-by-count":7,"title":["Brain Natriuretic Peptide and the Severity of Aortic Regurgitation: Is There Any Correlation?"],"prefix":"10.1177","volume":"33","author":[{"given":"M","family":"Ozkan","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Baysan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Cardiology, Gulhane Military Medical Academy, Ankara, 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