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Animals with the osteopetrosis (op\/op) mutation suffer from a general skeletal sclerosis, a significantly reduced number of macrophages and osteoclasts in various tissues, and have no systemic macrophage colony stimulating factor (M-CSF). This study examined the effect that M-CSF injections had on A\u03b2 deposition and microglial cell distribution in the brains of normal and op\/op mice. A\u03b2-positive plaques were detected in the cerebral cortex of op\/op mice, but not in normal mice. M-CSF reduced the numbers of A\u03b2-positive plaques in op\/op mice. The microglial cell population was reduced in op\/op mice compared with normal mice, and M-CSF increased the numbers to 65.8% of that observed in normal mice. Our results suggest that a clearer understanding of the role that microglial cells play in A\u03b2 deposition may help determine the mechanisms involved in the pathogenesis of Alzheimer's disease.<\/jats:p>","DOI":"10.1177\/147323000503300607","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"654-660","source":"Crossref","is-referenced-by-count":5,"title":["Amyloid \u03b2 Protein Deposition in Osteopetrotic (\n                    <i>op\/op<\/i>\n                    ) Mice Is Reduced by Injections of Macrophage Colony Stimulating Factor"],"prefix":"10.1177","volume":"33","author":[{"given":"T","family":"Kawata","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 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