{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:26:08Z","timestamp":1777724768134,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>This study evaluated the efficacy and safety of barnidipine for the treatment of mild-to-moderate essential hypertension in Chinese patients. A total of 131 patients were randomized to receive either barnidipine (10-15 mg) or felodipine (5-10 mg) once daily for 4 weeks. Both drugs reduced blood pressure significantly, with \u2265 87% of patients obtaining a marked or moderate effect. The mean \u00b1 SD reductions in systolic and diastolic blood pressure were 19.2 \u00b1 13.6 and 14.4 \u00b1 7.0 mmHg, respectively, for barnidipine treatment, and 20.3 \u00b1 11.3 and 14.7 \u00b1 7.7 mmHg, respectively, for felodipine treatment. There were no significant differences between the two drugs in terms of anti-hypertensive effect, heart rate, laboratory test results or incidence of adverse events. More patients taking felodipine experienced palpitations, but this difference was not statistically significant. Barnidipine is as efficacious and safe as felodipine in the treatment of essential hypertension in Chinese patients.<\/jats:p>","DOI":"10.1177\/147323000603400410","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"406-412","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Study of Barnidipine and Felodipine in Chinese Patients with Essential Hypertension"],"prefix":"10.1177","volume":"34","author":[{"given":"W","family":"Zhu","sequence":"first","affiliation":[{"name":"Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Li","sequence":"additional","affiliation":[{"name":"The Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Ni","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Liu","sequence":"additional","affiliation":[{"name":"The Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Fang","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Shang","sequence":"additional","affiliation":[{"name":"The Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kikkawa","sequence":"additional","affiliation":[{"name":"Asian Business Management, Astellas Pharma Co. 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