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The primary efficacy end-point was the Patient's Assessment of Ankle Pain visual analogue scale (VAS, 0-100 mm) value on day 4. Valdecoxib was as efficacious as diclofenac in treating the signs and symptoms of acute ankle sprain. The mean VAS reduction in ankle pain on day 4 was not different between groups; the two-sided 95% confidence interval for the between-group difference was within the pre-specified limit for non-inferiority (10 mm). There were no significant differences between groups for all secondary efficacy end-points. The two treatments were similarly effective and well tolerated for treatment of acute ankle sprain.<\/jats:p>","DOI":"10.1177\/147323000603400502","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"456-467","source":"Crossref","is-referenced-by-count":10,"title":["Valdecoxib Provides Effective Pain Relief following Acute Ankle Sprain"],"prefix":"10.1177","volume":"34","author":[{"given":"JA","family":"Diaz","sequence":"first","affiliation":[{"name":"Cl\u00ednica de Fracturas de Medell\u00edn, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Cuervo","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u2018Dr Jos\u00e9 Eleuterio Gonzalez\u2019, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey Nuevo, Le\u00f3n, 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