{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:26:33Z","timestamp":1777724793701,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>Intranasal polyposis is a chronic inflammatory upper airway disease with unknown aetiology. Interleukin (IL)-4 and IL-8 play very significant roles in allergic events and infectious inflammation, respectively. In contrast, E-selectin is important in the initiation and organization of inflammation. In this study, levels of IL-4, IL-8 and E-selectin were measured in nasal mucosa specimens of intranasal polyposis patients with and without allergic rhinitis, and healthy controls. Healthy controls had significantly higher IL-4 levels than allergic patients and non-allergic patients; IL-4 levels were similar in allergic and non-allergic patients. Allergic and non-allergic patients had significantly higher IL-8 levels than healthy controls; IL-8 levels were comparable in allergic and non-allergic patients. E-selectin levels were similar in all groups. The infection-based theory, represented by IL-8, seems to be more likely than the allergy-based theory, represented by IL-4, for the pathogenesis of nasal polyposis.<\/jats:p>","DOI":"10.1177\/147323000603400509","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"520-524","source":"Crossref","is-referenced-by-count":14,"title":["Interleukin-4, Interleukin-8 and E-selectin Levels in Intranasal Polyposis Patients with and without Allergy: A Comparative Study"],"prefix":"10.1177","volume":"34","author":[{"given":"A","family":"Ural","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Gazi University Faculty of Medicine, Gazi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MS","family":"Tezer","sequence":"additional","affiliation":[{"name":"First Otolaryngology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Department of Immunology, Gazi University Faculty of Medicine, Gazi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Atilla","sequence":"additional","affiliation":[{"name":"Otolaryngology Clinic, Ankara Elmadag Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"\u0130leri","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Gazi University Faculty of Medicine, Gazi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"bibr1-147323000603400509","first-page":"49","volume-title":"Nasal Polyps: Epidemiology, Pathogenesis and Treatment","author":"Jordana M","year":"1997"},{"key":"bibr2-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1159\/000053811"},{"key":"bibr3-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1080\/000164801300006326"},{"key":"bibr4-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200210000-00022"},{"key":"bibr5-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb04816.x"},{"key":"bibr6-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70100-8"},{"key":"bibr7-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-9702-9_2"},{"key":"bibr8-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00655.x"},{"key":"bibr9-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910100605"},{"key":"bibr10-147323000603400509","first-page":"95","volume-title":"Astma Patogenezi [Asthma Pathogenensis","author":"Turktas H","year":"1996","edition":"2"},{"key":"bibr11-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.5.1381"},{"key":"bibr12-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00998.x"},{"key":"bibr13-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70080-6"},{"key":"bibr14-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62806-2"},{"key":"bibr15-147323000603400509","doi-asserted-by":"publisher","DOI":"10.1007\/BF02484434"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000603400509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000603400509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:47Z","timestamp":1777459247000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000603400509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1177\/147323000603400509"],"URL":"https:\/\/doi.org\/10.1177\/147323000603400509","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}