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Peripheral blood lymphocytes from patients and 20 normal subjects (controls) were analysed in parallel. AITD was found to be associated with diminished TCR V\u03b2 gene family utilization. In addition, AITDs appeared to select for specific TCR V\u03b2 families. The V\u03b23, V\u03b25 and V\u03b28 families were expressed more frequently in thyroid-infiltrating T-lymphocytes of early-stage Graves' disease than other V\u03b2 gene families. Selective expression was not observed in infiltrating T-lymphocytes obtained from thyroid tissue of patients with late-stage Graves' disease or Hashimoto's disease. Preferentially expressed TCR V\u03b2 gene families may be useful as molecular targets for targeted immunotherapy of AITDs.<\/jats:p>","DOI":"10.1177\/147323000603400603","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"585-595","source":"Crossref","is-referenced-by-count":4,"title":["Infiltrating T-lymphocyte Receptor V\u03b2 Gene Family Utilization in Autoimmune Thyroid Disease"],"prefix":"10.1177","volume":"34","author":[{"given":"J","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Zhang","sequence":"additional","affiliation":[{"name":"Image Center, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 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