{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:28:29Z","timestamp":1777724909480,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>There is substantial evidence that the detection of T cells specific for the proteins ESAT-6 and CFP-10 using the ex vivo enzyme-linked immunospot technique is a marked improvement on the existing tuberculin skin test (TST). This new technique, which detects \u03b3-interferon-producing T cells, is now available as the commercial assay, T-Spot\u2122.TB. We compared the T-Spot\u2122.TB test with the TST for the diagnosis of latent tuberculosis infection (LTBI) in different groups of subjects. Significant accordance (85.7%) between the tests was found in subjects with active lung tuberculosis and in tuberculosis clinic and laboratory personnel (63.6%) but accordance was lowest and not significant amongst house contacts of tuberculosis patients (53.6%). We conclude that, in countries where vaccination is routinely performed, the T-Spot\u2122.TB test is a useful diagnostic test for LTBI in high-risk groups when carried out either together with the TST and\/or to confirm the TST result.<\/jats:p>","DOI":"10.1177\/147323000703500515","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"696-703","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of Tuberculin Skin Test and a Specific T-cell-based Test, T-Spot\u2122. TB, for the Diagnosis of Latent Tuberculosis Infection"],"prefix":"10.1177","volume":"35","author":[{"given":"T","family":"Ozekinci","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ozbek","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,9,1]]},"reference":[{"key":"bibr1-147323000703500515","unstructured":"World Health Organization: WHO Report 2006. Global Tuberculosis Control. Surveillance, Planning, Financing. Available at: http:\/\/www.who.int\/tb\/publications\/global_report\/2006\/pdf\/full_report_correctedversion.pdf (last accessed 3 July 2007)."},{"key":"bibr2-147323000703500515","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1183\/09031936.02.00261402","volume":"19","author":"Broekmans JF","year":"2002","journal-title":"Eur Respir J"},{"key":"bibr3-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp021045"},{"key":"bibr4-147323000703500515","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.16585"},{"key":"bibr5-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5419.1520"},{"key":"bibr6-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02742-2"},{"key":"bibr7-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-1377-8"},{"key":"bibr8-147323000703500515","volume-title":"T\u00fcrkiye'de Tuberk\u00fclozun Kontrol\u00fc I\u00e7in Ba\u015fvuru Kitabi","author":"\u00d6zkara \u015e","year":"2003"},{"key":"bibr9-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2404004"},{"key":"bibr10-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.6.968"},{"key":"bibr11-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00016906"},{"key":"bibr12-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00107005"},{"key":"bibr13-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12950-9"},{"key":"bibr14-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.4.2009100"},{"key":"bibr15-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200211220-00008"},{"key":"bibr16-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17592-2"},{"key":"bibr17-147323000703500515","first-page":"1242","volume":"9","author":"Zellweger JP","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"bibr18-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2095"},{"key":"bibr19-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00005906"},{"key":"bibr20-147323000703500515","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.2.704-706.2002"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000703500515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000703500515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:06Z","timestamp":1777459266000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000703500515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1177\/147323000703500515"],"URL":"https:\/\/doi.org\/10.1177\/147323000703500515","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}