{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:55:02Z","timestamp":1778356502876,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>Etomidate is a popular anaesthetic induction agent, but it frequently causes myoclonic movements. Although both benzodiazepines and opioids reduce myoclonus, there has been no comparative study between these agents. Thus, we conducted a prospective, randomized study to compare midazolam and remifentanil as pre-treatment agents for reducing etomidate-induced myoclonus in 90 adults undergoing surgery. Patients were pre-treated before the etomidate injection, either with saline (Group C), midazolam 0.5 mg\/kg (Group M) or remifentanil 1 \u03bcg\/kg (Group R). Both Groups M and R showed a significantly lower incidence of myoclonus compared with Group C (17%, 17% and 77%, respectively). The incidence of myoclonus was not significantly different between Groups M and R, but 10% ( n = 10) of the patients in Group R experienced remifentanil-related side-effects. We conclude that midazolam is probably a better choice than remifentanil for reducing etomidate-induced myoclonus during anaesthesia induction.<\/jats:p>","DOI":"10.1177\/147323000803600103","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"17-22","source":"Crossref","is-referenced-by-count":30,"title":["A Comparison of Midazolam with Remifentanil for the Prevention of Myoclonic Movements following Etomidate Injection"],"prefix":"10.1177","volume":"36","author":[{"given":"J-Y","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Bundang Hospital, Seoul National University, Bundang-gu, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-H","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Bundang Hospital, Seoul National University, Bundang-gu, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-Y","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Bundang Hospital, Seoul National University, Bundang-gu, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-H","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Bundang Hospital, Seoul National University, Bundang-gu, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y-T","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Bundang Hospital, Seoul National University, Bundang-gu, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-H","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Bundang Hospital, Seoul National University, Bundang-gu, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,1,1]]},"reference":[{"key":"bibr1-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0303100103"},{"key":"bibr2-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199901000-00017"},{"key":"bibr3-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X8801600207"},{"key":"bibr4-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198509000-00006"},{"key":"bibr5-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198908000-00022"},{"key":"bibr6-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.00081.x"},{"key":"bibr7-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2005.05.004"},{"key":"bibr8-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/51.12.1151"},{"key":"bibr9-147323000803600103","first-page":"201","volume":"35","author":"Fassoulaki A","year":"1987","journal-title":"Cah Anesthesiol"},{"key":"bibr10-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2006.07.079"},{"key":"bibr11-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(02)00404-X"},{"key":"bibr12-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2000.440704.x"},{"key":"bibr13-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1997.24-az0051.x"},{"key":"bibr14-147323000803600103","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199705000-00007"},{"key":"bibr15-147323000803600103","first-page":"40","volume":"10","author":"Raza SM","year":"1987","journal-title":"Clin Ther"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000803600103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000803600103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:15Z","timestamp":1777459275000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000803600103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1177\/147323000803600103"],"URL":"https:\/\/doi.org\/10.1177\/147323000803600103","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}