{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:31:21Z","timestamp":1777725081271,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>\n                    This study examined the influence of milk casein-derived peptides on cerebral activity after mental stress loading. In a crossover study, 16 male students were given a drink containing peptides (peptide group), or water (control group) before stress loading. The oxyhaemoglobin (HbO\n                    <jats:sub>2<\/jats:sub>\n                    ) concentration in the prefrontal area of the brain and work efficiency were measured as indicators of cerebral activity and differences in these parameters were examined according to type A or type B personality. Type A behaviour was defined as: aggression\u2013hostility, hard-driving\u2014time-urgency and speed\u2013power, whereas type B behaviour did not have these characteristics. Peptide intake resulted in a significant increase in both HbO\n                    <jats:sub>2<\/jats:sub>\n                    concentration and work efficiency, whilst a similar increase was not seen in the control group. When divided into type A or type B personality, the changes in HbO\n                    <jats:sub>2<\/jats:sub>\n                    concentration for the control group differed significantly in the right prefrontal area. Moreover, in type A subjects the HbO\n                    <jats:sub>2<\/jats:sub>\n                    concentration in the right prefrontal area following intake was significantly different between the peptide and control groups.\n                  <\/jats:p>","DOI":"10.1177\/147323000803600404","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"638-647","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Milk Casein-derived Peptides on Absolute Oxyhaemoglobin Concentrations in the Prefrontal Area and on Work Efficiency after Mental Stress Loading in Male Students"],"prefix":"10.1177","volume":"36","author":[{"given":"H","family":"Nakamura","sequence":"first","affiliation":[{"name":"Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd, Zama, Kanagawa, 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