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In total, 78 OSAS patients (43 receiving nCPAP; 35 receiving lifestyle guidance) were included in the study. nCPAP treatment had a minor effect on the total HRQoL score; only the dimension of sleep improved in both groups. The mean \u00b1 SD number of quality-adjusted life years (QALYs) gained was 0.016 \u00b1 2.34 in the nCPAP group and 0.386 \u00b1 1.16 in the lifestyle guidance group. The mean cost per QALY gained was \u20ac73 375 for the nCPAP group and \u20ac845 for the lifestyle guidance group. The effect of nCPAP treatment on the HRQoL in a population of unselected OSAS patients was surprisingly small and the cost per QALY gained was high.<\/jats:p>","DOI":"10.1177\/147323000803600418","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"760-770","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Nasal Continuous Positive Airway Pressure Therapy on Health-related Quality of Life in Sleep Apnoea Patients Treated in the Routine Clinical Setting of a University Hospital"],"prefix":"10.1177","volume":"36","author":[{"given":"J","family":"Lojander","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Jorvi Hospital, Helsinki University Central Hospital, Espoo, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[{"name":"Group Administration, Helsinki and Uusimaa Hospital Group, HUS, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sintonen","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RP","family":"Roine","sequence":"additional","affiliation":[{"name":"Group Administration, Helsinki and Uusimaa Hospital Group, HUS, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"HUS QoL Study Group*","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"bibr1-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7459.224"},{"key":"bibr2-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.015867"},{"key":"bibr3-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.3.861"},{"key":"bibr4-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92089-3"},{"key":"bibr5-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(85)90138-9"},{"key":"bibr6-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/18.8.635"},{"key":"bibr7-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"bibr8-147323000803600418","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00019"},{"key":"bibr9-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7084.851"},{"key":"bibr10-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195108248.001.0001"},{"key":"bibr11-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/94.2.95"},{"key":"bibr12-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.2.9712036"},{"key":"bibr13-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462306051051"},{"key":"bibr14-147323000803600418","first-page":"52","volume":"17","author":"Tousignant P","year":"1994","journal-title":"Sleep"},{"key":"bibr15-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00.00014401"},{"key":"bibr16-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.4.1241"},{"key":"bibr17-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16a21.x"},{"key":"bibr18-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008845123907"},{"key":"bibr19-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00298103"},{"key":"bibr20-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.2.255"},{"key":"bibr21-147323000803600418","unstructured":"15D The Health-related Quality of Life (HRQoL) Instrument. http:\/\/www.15d-instrument.net\/15D."},{"key":"bibr22-147323000803600418","first-page":"182","volume":"34","author":"Sintonen H","year":"1997","journal-title":"J Soc Med"},{"key":"bibr23-147323000803600418","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002086"},{"key":"bibr24-147323000803600418","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026475531996"},{"key":"bibr25-147323000803600418","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002090"},{"key":"bibr26-147323000803600418","unstructured":"Aromaa A, Koskinen S: Health and Functional Capacity in Finland. 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