{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T19:59:17Z","timestamp":1787255957102,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>This study aimed to characterize the role of the mitogen-activated protein kinase (MAPK) kinase (MEK)\/extracellular signal-regulated kinase (ERK) pathway in cardiac hypertrophy induced by parathyroid hormone (PTH). Various concentrations of rat PTH1\u201334 were used to induce hypertrophy in neonatal rat ventricular cardiomyocytes, and the effects were compared with control cells and those treated with PD98059, a selective inhibitor of MEK1. Hypertrophy was assessed in terms of cell diameter, atrial natriuretic peptide (ANP) mRNA expression and protein synthesis; the MEK\/ERK pathway was assessed by measuring levels of phosphorylated ERK1\/2. Treatment with PTH1\u201334 at 100 nM for 24 h effectively induced cardiac hypertrophy (increased cell diameter, protein synthesis and ANP mRNA expression) and also increased levels of phosphorylated ERK1\/2 compared with normal control cells. Treatment with PTH1\u201334 plus PD98059 significantly attenuated these changes. These results demonstrate that inhibition of the MEK\/ERK pathway blocks PTH1\u201334-induced cardiac hypertrophy, suggesting that PTH1\u201334 might signal through the MAPK pathway to induce hypertrophy in cardiomyocytes.<\/jats:p>","DOI":"10.1177\/147323000803600510","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"942-950","source":"Crossref","is-referenced-by-count":18,"title":["Rat Parathyroid Hormone 1 \u2212 34 Signals through the MEK\/ERK Pathway to Induce Cardiac Hypertrophy"],"prefix":"10.1177","volume":"36","author":[{"given":"X","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology, The Second Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"bibr1-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1053\/jarr.2002.34842"},{"key":"bibr2-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80977-2"},{"key":"bibr3-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40553-1"},{"key":"bibr4-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004070597"},{"key":"bibr5-147323000803600510","volume-title":"USRDS 2002 Annual Data Report","author":"United States Renal Data System","year":"2002"},{"key":"bibr6-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200102000-00002"},{"key":"bibr7-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.113218"},{"key":"bibr8-147323000803600510","first-page":"67","volume":"31","author":"Nasri H","year":"2004","journal-title":"Acta Med Austriaca"},{"key":"bibr9-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005000900016"},{"key":"bibr10-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110137"},{"key":"bibr11-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00194-6"},{"key":"bibr12-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.6.3074"},{"key":"bibr13-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000177984.76186.70"},{"key":"bibr14-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1385\/CBB:47:1:21"},{"key":"bibr15-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20151"},{"key":"bibr16-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000159339.00703.22"},{"key":"bibr17-147323000803600510","doi-asserted-by":"crossref","first-page":"11087","DOI":"10.1016\/S0021-9258(18)60431-4","volume":"264","author":"Schl\u00fcter KD","year":"1989","journal-title":"J Biol Chem"},{"key":"bibr18-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2007.8"},{"key":"bibr19-147323000803600510","first-page":"41","volume":"25","author":"Zhang SQ","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"bibr20-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.542209"},{"key":"bibr21-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.03.003"},{"key":"bibr22-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1135"},{"key":"bibr23-147323000803600510","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(01)00139-5"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000803600510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000803600510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:37Z","timestamp":1777459297000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000803600510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1177\/147323000803600510"],"URL":"https:\/\/doi.org\/10.1177\/147323000803600510","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}