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Inflammatory processes are also involved, leading to stiffness and pain, for which patients seek treatment. Conventional treatment includes analgesics or non-steroidal antiinflammatory drugs, however life-style changes should also be recommended, such as weight reduction and specific exercises. Glucosamine and chondroitin, classed as over-the-counter supplements or nutraceuticals, are regularly self-administered by patients with OA. Both agents are produced endogenously in the human body and are essential components of cartilage. This review discusses the evidence that supports the use of these agents either alone or in combination for pain relief and as disease-modifying agents in OA.<\/jats:p>","DOI":"10.1177\/147323000803600602","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"1161-1179","source":"Crossref","is-referenced-by-count":72,"title":["Glucosamine and Chondroitin for Osteoarthritis"],"prefix":"10.1177","volume":"36","author":[{"given":"EC","family":"Huskisson","sequence":"first","affiliation":[{"name":"King Edward VII Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"bibr1-147323000803600602","first-page":"82","volume-title":"ABC of Rheumatology","author":"Spector TD","year":"1999","edition":"2"},{"key":"bibr2-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200009)43:9<1905::AID-ANR1>3.0.CO;2-P"},{"key":"bibr3-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71086-2"},{"key":"bibr4-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1248220"},{"key":"bibr5-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380103"},{"key":"bibr6-147323000803600602","first-page":"511","volume-title":"Practical Rheumatology","author":"Lozada CJ","year":"2004","edition":"3"},{"key":"bibr7-147323000803600602","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2005.004"},{"key":"bibr8-147323000803600602","first-page":"62","volume-title":"Oxford Textbook of Medicine","author":"Brion PH","year":"2004","edition":"4"},{"key":"bibr9-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.18.2113"},{"key":"bibr10-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.13.1514"},{"key":"bibr11-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.01.007"},{"key":"bibr12-147323000803600602","first-page":"27","volume":"3","author":"Kelly GS","year":"1998","journal-title":"Altern Med Rev"},{"key":"bibr13-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200012000-00027"},{"key":"bibr14-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70074-0"},{"key":"bibr15-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052771"},{"key":"bibr16-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0308"},{"key":"bibr17-147323000803600602","first-page":"571","volume":"49","author":"Denham AC","year":"2000","journal-title":"J Fam Pract"},{"key":"bibr18-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/164.2.85"},{"key":"bibr19-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.1998.11746062"},{"key":"bibr20-147323000803600602","first-page":"699","volume":"51","author":"Setnikar I","year":"2001","journal-title":"Arzneimittelforschung"},{"key":"bibr21-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1345\/aph.17235"},{"key":"bibr22-147323000803600602","first-page":"2423","volume":"26","author":"Houpt JB","year":"1999","journal-title":"J Rheumatol"},{"key":"bibr23-147323000803600602","first-page":"538","volume":"3","author":"Setnikar I","year":"1984","journal-title":"Pharmatherapeutica"},{"key":"bibr24-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.01.019"},{"key":"bibr25-147323000803600602","first-page":"918","volume":"45","author":"Conte A","year":"1995","journal-title":"Arzneimittelforschung"},{"key":"bibr26-147323000803600602","first-page":"1863","volume":"27","author":"Conrozier T","year":"1998","journal-title":"Presse Med"},{"key":"bibr27-147323000803600602","first-page":"27","volume":"13","author":"Ronca G","year":"1993","journal-title":"Int J Clin Pharmacol Res"},{"key":"bibr28-147323000803600602","first-page":"319","volume":"40","author":"Palmieri L","year":"1990","journal-title":"Arzneimittelforschung"},{"key":"bibr29-147323000803600602","first-page":"768","volume":"41","author":"Conte A","year":"1991","journal-title":"Arzneimittelforschung"},{"key":"bibr30-147323000803600602","first-page":"27","volume":"17","author":"Conte A","year":"1991","journal-title":"Drugs Exp Clin Res"},{"key":"bibr31-147323000803600602","first-page":"286","volume":"54","author":"Barthe L","year":"2004","journal-title":"Arzneimittelforschung"},{"key":"bibr32-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0824"},{"key":"bibr33-147323000803600602","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(98)80006-X"},{"key":"bibr34-147323000803600602","first-page":"75","volume":"44","author":"Reichelt A","year":"1994","journal-title":"Arzneimittelforschung"},{"key":"bibr35-147323000803600602","volume-title":"Glucosamine, chondoitin and joint health. 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