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To investigate the expression of ubiquitin in monocytes and lymphocytes isolated from patients at different stages of CAD, 120 patients with CAD (40 with acute myocardial infarction [AMI], 40 with unstable angina pectoris [UAP] and 40 with stable angina pectoris [SAP]) were selected; 40 patients with normal coronary arteries served as controls. At both the mRNA and protein levels, ubiquitin expression was higher in patients with CAD than in controls, and patients with AMI had a much higher expression of ubiquitin (at both the mRNA and protein levels) than those with SAP and UAP. These data indicate that ubiquitin expression increased with increasing severity of CAD, suggesting that ubiquitin may play a critical role in the development and progression of CAD.<\/jats:p>","DOI":"10.1177\/147323000803600609","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"1227-1234","source":"Crossref","is-referenced-by-count":6,"title":["Expression of Ubiquitin in Peripheral Inflammatory Cells from Patients with Coronary Artery Disease"],"prefix":"10.1177","volume":"36","author":[{"given":"S-M","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Medical College, Shantou University, Shantou Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-X","family":"Zhang","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Department, Guangdong Provincial People's Hospital, Guangzhou 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