{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:52:42Z","timestamp":1792270362239,"version":"4.4.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>Blood rheology, fasting serum concentrations of remnant-like lipoprotein particle cholesterol (RLP-C) and concentrations of other lipids were compared in 23 hypercholesterolaemic and 69 normocholesterolaemic subjects, and the relationship between red blood cell (RBC) deformability and RLP-C concentrations were studied in a different set of six hypercholesterolaemic and six normocholesterolaemic subjects. Passage time of whole blood and concentrations of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and RLP-C were significantly higher in hypercholesterolaemic than in normocholesterolaemic subjects. Passage time of whole blood correlated positively with TC, TG, LDL-C and RLP-C and negatively with high-density lipoprotein cholesterol. Furthermore, the passage time of 10% haematocrit-adjusted RBCs in phosphate-buffered saline, which reflects RBC deformability, correlated positively with the passage time of whole blood and RLP-C. Thus, hypercholesterolaemic subjects had impaired blood rheology and elevated RLP-C concentrations, which may be associated with the pathophysiology of atherosclerosis in hypercholesterolaemic subjects. Impaired RBC deformability may contribute to impaired blood rheology associated with elevated RLP-C in hypercholesterolaemic subjects.<\/jats:p>","DOI":"10.1177\/147323000903700204","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"308-317","source":"Crossref","is-referenced-by-count":12,"title":["Impaired Blood Rheology and Elevated Remnant-like Lipoprotein Particle Cholesterol in Hypercholesterolaemic Subjects"],"prefix":"10.1177","volume":"37","author":[{"given":"M","family":"Nara","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Sumino","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Nursing, Takasaki University of Health and Welfare, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nara","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Machida","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Amagai","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Innovation Center for Cooperative Research, Gunma University, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"bibr1-147323000903700204","first-page":"933","author":"Martin MJ","year":"1982","journal-title":"Lancet"},{"key":"bibr2-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.6.2762"},{"key":"bibr3-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.1.153"},{"key":"bibr4-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(93)90062-9"},{"key":"bibr5-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.6.1224"},{"key":"bibr6-147323000903700204","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-12-199306150-00008"},{"key":"bibr7-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.18.1477"},{"key":"bibr8-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.3.836"},{"key":"bibr9-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.5.768"},{"key":"bibr10-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.8532481.x"},{"key":"bibr11-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.15.1467"},{"key":"bibr12-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.6.2197"},{"key":"bibr13-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648148"},{"key":"bibr14-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90096-R"},{"key":"bibr15-147323000903700204","first-page":"217","volume":"24","author":"Kurihara T","year":"2001","journal-title":"Clin Hemorheol Microcirc"},{"key":"bibr16-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(92)90082-Z"},{"key":"bibr17-147323000903700204","first-page":"401","volume":"34","author":"Seki K","year":"2006","journal-title":"Clin Hemorheol Microcirc"},{"key":"bibr18-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1177\/147323000503300204"},{"key":"bibr19-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2005.05.018"},{"key":"bibr20-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1177\/147323000603400412"},{"key":"bibr21-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.2001.2307"},{"key":"bibr22-147323000903700204","doi-asserted-by":"publisher","DOI":"10.5551\/jat1973.25.1-2_1"},{"key":"bibr23-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2003.12.006"},{"key":"bibr24-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00144-0"},{"key":"bibr25-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(89)90105-6"},{"key":"bibr26-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(83)84288-X"},{"key":"bibr27-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(81)90107-6"},{"key":"bibr28-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(77)90196-4"},{"key":"bibr29-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.11.1775"},{"key":"bibr30-147323000903700204","first-page":"301","volume":"30","author":"Cicha I","year":"2004","journal-title":"Clin Hemorheol Microcirc"},{"key":"bibr31-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00643-X"},{"key":"bibr32-147323000903700204","first-page":"423","volume":"30","author":"Contreras T","year":"2004","journal-title":"Clin Hemorheol Microcirc"},{"key":"bibr33-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2001.00785.x"},{"key":"bibr34-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1656092"},{"key":"bibr35-147323000903700204","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00368-3"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000903700204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000903700204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:58Z","timestamp":1777459318000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000903700204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1177\/147323000903700204"],"URL":"https:\/\/doi.org\/10.1177\/147323000903700204","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}