{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:01:46Z","timestamp":1785769306817,"version":"3.56.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>Orexin-A is a neuropeptide involved in the regulation of food intake and the sleep-wake cycle. This study investigated plasma orexin-A levels in a sleep clinic cohort, adjusting for smoking habits, in 76 participants comprising 41 with obstructive sleep apnoea (OSA) (apnoea-hypopnoea index [AHI] 44.1 \u00b1 19.1 events\/h) and 35 without OSA (AHI 6.3 \u00b1 4.7 events\/h). Plasma orexin-A levels were significantly lower in OSA patients (15.0 \u00b1 4.6 ng\/ml) compared with those without OSA (31.4 \u00b1 6.5 ng\/ml). In non-OSA subjects, there was no significant difference between never smokers and ex\/current smokers in plasma orexin-A levels (32.9 \u00b1 9.5 versus 29.7 \u00b1 8.9 ng\/ml, respectively) whereas, in the OSA sub-group, orexin-A levels were significantly lower in never smokers than in ex\/current smokers (4.0 \u00b1 1.2 versus 21.4 \u00b1 7.0 ng\/ml). A significant inverse relationship was found between plasma orexin-A levels and AHI amongst never smokers, but there was no significant relationship amongst ex\/current smokers. These results confirm previous studies demonstrating lower levels of plasma orexin-A in OSA patients and indicate that smoking may affect orexin-A levels and AHI.<\/jats:p>","DOI":"10.1177\/147323000903700207","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"331-340","source":"Crossref","is-referenced-by-count":25,"title":["Obstructive Sleep Apnoea, Cigarette Smoking and Plasma Orexin-A in a Sleep Clinic Cohort"],"prefix":"10.1177","volume":"37","author":[{"given":"K","family":"Aksu","sequence":"first","affiliation":[{"name":"Sleep Disorders Centre, Department of Pulmonology, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Firat","family":"G\u00fcven","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre, Department of Pulmonology, Atat\u00fcrk Chest Diseases and Chest 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