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In this study, inhibition of Bcr-Abl tyrosine kinase activity by imatinib significantly decreased VEGF expression in Bcr-Abl-positive K562 cells in vitro Imatinib treatment in vivo of nude mice xenografted with K562 cells resulted in a significant reduction in tumour size and microvessel density compared with untreated tumours. In addition, interfering with Bcr-Abl oncogene expression with small interfering RNAs (siRNAs) not only induced a specific reduction of Bcr-Abl mRNA and protein expression, but also efficiently inhibited the expression of VEGF in K562 cells. Combined treatment with imatinib and Bcr-Abl-targeting siRNAs resulted in an enhanced effect on VEGF suppression in K562 cells. The combined application of Bcr-Abl-targeting siRNAs and imatinib may provide a potent novel therapeutic approach for chronic myeloid leukaemia.<\/jats:p>","DOI":"10.1177\/147323000903700218","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"426-437","source":"Crossref","is-referenced-by-count":3,"title":["Suppression of Vascular Endothelial Growth Factor (VEGF) Expression by Targeting the\n                    <i>Bcr-Abl<\/i>\n                    Oncogene and Protein Tyrosine Kinase Activity in Bcr-Abl-positive Leukaemia Cells"],"prefix":"10.1177","volume":"37","author":[{"given":"L","family":"Li","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Soochow University, Jiangsu Institute of Haematology, Key Laboratory of Thrombosis and Haemostasis, Ministry of Health, Suzhou, China"},{"name":"Suzhou Red Cross Blood Centre, Suzhou, 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