{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:36:46Z","timestamp":1777725406047,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>\n                    This study characterized CXC chemokine receptor 4 (CXCR4) expression in patients with mitral valve disease and chronic atrial fibrillation (AF). Forty-eight patients with chronic AF formed two groups based on whether they were treated with or without renin\u2013angiotensin system (RAS) blockers (AF + RAS group; n = 25, or AF \u2013 RAS group; n = 23). The controls comprised 17 mitral valve disease patients with sinus rhythm (SR group). CXCR4 mRNA and protein levels in the left atria were significantly higher in the AF \u2013 RAS and AF + RAS groups than in the SR group. CXCR4 expression was significantly lower in the AF + RAS group than the AF \u2013 RAS group. More CD34\n                    <jats:sup>+<\/jats:sup>\n                    cells expressed CXCR4 in the AF \u2013 RAS and AF + RAS groups than in the SR group. Angiotensin II, collagen I and left atrial diameter significantly positively correlated with CXCR4 expression in the AF \u2013 RAS group. These results suggest that CXCR4 expression is up-regulated in chronic AF patients with mitral valve disease, is associated with atrial remodelling, and that these effects are attenuated by RAS blockers.\n                  <\/jats:p>","DOI":"10.1177\/147323000903700419","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"1145-1151","source":"Crossref","is-referenced-by-count":13,"title":["Up-Regulation of CXC Chemokine Receptor 4 Expression in Chronic Atrial Fibrillation Patients with Mitral Valve Disease May Be Attenuated by Renin\u2013Angiotensin System Blockers"],"prefix":"10.1177","volume":"37","author":[{"given":"XX","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FR","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JH","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XD","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JZ","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"bibr1-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1038\/415219a"},{"key":"bibr2-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.064"},{"key":"bibr3-147323000903700419","first-page":"2444","volume":"51","author":"Casaclang Verzosa G","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"bibr4-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200418847"},{"key":"bibr5-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420997"},{"key":"bibr6-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1038\/ni1251"},{"key":"bibr7-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5403.845"},{"key":"bibr8-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.11.010"},{"key":"bibr9-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0187OC"},{"key":"bibr10-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2007.01.003"},{"key":"bibr11-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.045"},{"key":"bibr12-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.07.014"},{"key":"bibr13-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0284-5"},{"key":"bibr14-147323000903700419","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.08.008"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000903700419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000903700419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:42:16Z","timestamp":1777459336000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000903700419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1177\/147323000903700419"],"URL":"https:\/\/doi.org\/10.1177\/147323000903700419","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}