{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:39:53Z","timestamp":1778945993749,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>The objective of this study was to evaluate the efficacy of treating chronic idiopathic urticaria (CIU) with levamisole in combination with levocetirizine. This was a multicentre, randomized, double-blind, controlled trial that included 132 patients with active CIU who were treated for 6 weeks with either levocetirizine alone (control group; n = 65) or levamisole plus levocetirizine (treatment group; n = 67). Response to therapy was evaluated by measuring the efficacy rate. After 2 weeks of treatment, there was no significant difference in the efficacy rate between the treatment and control groups (54.84% and 42.37%, respectively). After 6 weeks of treatment, a statistically significant difference in the efficacy rate was observed between the groups (76.27% and 54.39% for the treatment and control groups, respectively). This study demonstrated that a combination of levamisole plus levocetirizine is more effective than levocetirizine alone and potentially provides a new, promising approach to the treatment of CIU.<\/jats:p>","DOI":"10.1177\/147323000903700422","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:43Z","timestamp":1361974963000},"page":"1167-1172","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of Chronic Idiopathic Urticaria with Levamisole: A Multicentre, Randomized, Double-Blind, Controlled Trial"],"prefix":"10.1177","volume":"37","author":[{"given":"H","family":"Zhang","sequence":"first","affiliation":[{"name":"Affiliated Yancheng Hospital, Medical College of Southeast University, Yancheng, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Shan","sequence":"additional","affiliation":[{"name":"Affiliated Yancheng Hospital, Medical College of Southeast University, Yancheng, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Hua","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Nantong University, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Zhao","sequence":"additional","affiliation":[{"name":"Affiliated Jiangyin Hospital, Medical College of Southeast University, Jiangyin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xinghua Traditional Chinese Hospital, Xinghua, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"bibr1-147323000903700422","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200310000-00008"},{"key":"bibr2-147323000903700422","doi-asserted-by":"publisher","DOI":"10.1159\/000058004"},{"key":"bibr3-147323000903700422","doi-asserted-by":"publisher","DOI":"10.1159\/000066772"},{"key":"bibr4-147323000903700422","doi-asserted-by":"publisher","DOI":"10.1080\/000155502320323199"},{"key":"bibr5-147323000903700422","volume-title":"Remington: the Science and Practice of Pharmacy","author":"Gennaro AR","year":"1995","edition":"19"},{"key":"bibr6-147323000903700422","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200405020-00004"},{"key":"bibr7-147323000903700422","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(94)90090-6"},{"key":"bibr8-147323000903700422","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00042.x"},{"key":"bibr9-147323000903700422","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120037655"},{"key":"bibr10-147323000903700422","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.123236"},{"key":"bibr11-147323000903700422","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.03.016"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000903700422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000903700422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:42:17Z","timestamp":1777459337000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000903700422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1177\/147323000903700422"],"URL":"https:\/\/doi.org\/10.1177\/147323000903700422","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}