{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:18:27Z","timestamp":1792639107102,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>\n                    Serum cystatin C concentrations are reported to increase in the hyperthyroid state. Serum concentrations of cystatin C and transforming growth factor-\u03b21 (TGF-\u03b21) were measured in patients with thyroid dysfunction, and the effects of 3,5,3\u2032-tri-iodothyronine (T\n                    <jats:sub>3<\/jats:sub>\n                    ) and TGF-\u03b21 on cystatin C production in human hepatoblastoma (Hep G2) cells were studied. Serum concentrations of cystatin C and TGF-\u03b21 were significantly higher in patients with Graves' disease compared with control subjects. Significantly positive correlations were observed between thyroid hormones and cystatin C, thyroid hormones and TGF-\u03b21, and TGF-\u03b21 and cystatin C in patients with thyroid dysfunction. Serum concentrations of cystatin C and TGF-\u03b21 decreased after treatment for hyperthyroidism. Cystatin C mRNA levels and cystatin C secretion were increased by T\n                    <jats:sub>3<\/jats:sub>\n                    and TGF-\u03b21 in cultured Hep G2 cells. These results suggest that serum cystatin C concentrations increase in patients with hyperthyroidism. The mechanisms for this may involve elevation of serum TGF-\u03b21 levels and the stimulatory effects of T\n                    <jats:sub>3<\/jats:sub>\n                    and TGF-\u03b21 on cystatin C production.\n                  <\/jats:p>","DOI":"10.1177\/147323001003800418","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1365-1373","source":"Crossref","is-referenced-by-count":35,"title":["Influence of Thyroid Hormones and Transforming Growth Factor-\u03b21 on Cystatin C Concentrations"],"prefix":"10.1177","volume":"38","author":[{"given":"N","family":"Kotajima","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma 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