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High-resolution 3-T cerebral magnetic resonance imaging scans were acquired in 10 female, right-handed, non-smoking, white Caucasian subjects: five patients with fibromyalgia associated with marked fatigue and five age-matched healthy women. Voxel-wise generalized linear modelling of the processed neuroanatomical data using permutation-based non-parametric testing, forming clusters at t &gt; 2.3 and testing clusters for significance at P &lt; 0.05, corrected for multiple comparisons across space, revealed significantly lower grey matter density in the patients with fibromyalgia and marked fatigue in the left supplementary motor area. This brain region plays an important role in cognitive or executive control and in the translation of painful cognition; these functions are impaired in fibromyalgia associated with marked fatigue.<\/jats:p>","DOI":"10.1177\/147323001003800429","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1468-1472","source":"Crossref","is-referenced-by-count":20,"title":["Reduction in Left Supplementary Motor Area Grey Matter in Adult Female Fibromyalgia Sufferers with Marked Fatigue and without Affective Disorder: A Pilot Controlled 3-T Magnetic Resonance Imaging Voxel-Based Morphometry Study"],"prefix":"10.1177","volume":"38","author":[{"given":"BK","family":"Puri","sequence":"first","affiliation":[{"name":"Imaging Department, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK"},{"name":"University of Limerick, Limerick, Republic of 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