{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:32:44Z","timestamp":1783981964204,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>Microarray searches have revealed potential genetic biomarkers in a wide variety of human diseases. Identification of biomarkers for disease status is particularly important in chronic neurodegenerative diseases where brain tissue cannot be sampled. A previous study identified 12 genes from microarray analysis as associated with Huntington's disease, although the relationships had not been validated. We used new machine learning approaches to reanalyse those microarray data and to rank the identified potential genetic biomarkers. We then performed quantitative reverse transcription\u2013polymerase chain reaction analysis on a subset of the candidate genes in blood samples from an independent cohort of 23 Huntington's disease patients and 23 healthy controls. Our highest ranked genes did not overlap with the 12 previously identified, but two were significantly up-regulated in the Huntington's disease group: ARFGEF2 and GOLGA8G. Little is known about the latter, but the former warrants further analysis as it is known to be associated with intracellular vesicular trafficking, disturbances of which characterize Huntington's disease.<\/jats:p>","DOI":"10.1177\/147323001003800510","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1653-1662","source":"Crossref","is-referenced-by-count":11,"title":["ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (ARFGEF2): A New Potential Biomarker in Huntington's Disease"],"prefix":"10.1177","volume":"38","author":[{"given":"L","family":"Lovrecic","sequence":"first","affiliation":[{"name":"Institute of Medical Genetics, Division of Gynaecology, University Medical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Slavkov","sequence":"additional","affiliation":[{"name":"Department of Knowledge Technologies, Jo\u017eef Stefan Institute, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"D\u017eeroski","sequence":"additional","affiliation":[{"name":"Department of Knowledge Technologies, Jo\u017eef Stefan Institute, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Peterlin","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, Division of Gynaecology, University Medical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"bibr1-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199805000-00001"},{"key":"bibr2-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20071619"},{"key":"bibr3-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"bibr4-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(03)00168-3"},{"key":"bibr5-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290235"},{"key":"bibr6-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000186842.51129.cb"},{"key":"bibr7-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"bibr8-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.1.1"},{"key":"bibr9-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504921102"},{"key":"bibr10-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703652104"},{"key":"bibr11-147323001003800510","volume-title":"A Distributed Computing System for the Complete Validation of Gene Profiles","author":"Albanese D","year":"2005"},{"key":"bibr12-147323001003800510","volume-title":"Statistical Learning Theory (Adaptive and Learning Systems for Signal Processing, Communication and Control Series)","author":"Vapnik V","year":"1998"},{"key":"bibr13-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012487302797"},{"key":"bibr14-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-4-54"},{"key":"bibr15-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"bibr16-147323001003800510","first-page":"365","volume":"132","author":"Rozen S","year":"2000","journal-title":"Methods Mol Biol"},{"key":"bibr17-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1139\/o06-181"},{"key":"bibr18-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.11.001"},{"key":"bibr19-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2007.10.010"},{"key":"bibr20-147323001003800510","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-S1-S13"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323001003800510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323001003800510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:43:12Z","timestamp":1777459392000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323001003800510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1177\/147323001003800510"],"URL":"https:\/\/doi.org\/10.1177\/147323001003800510","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}