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Rabbit facial nerves were injured by clamping and then treated with recombinant human BMP-2 (rhBMP-2) or phosphate-buffered saline (control) by injecting once during surgery and twice a day post-injury for 7 days. Facial nerve fragments within 5 mm of the clamping point were examined at different times post-surgery. Axon structures visualized by Bielschowsky staining were similar in experimental and control nerves 2 and 6 weeks post-injury. At 4 weeks post-injury, cross-section images of facial nerves showed that axons treated with rhBMP-2 were denser and thicker, and levels of tau protein were increased. It is concluded from these data that rhBMP-2 may affect injured facial nerve regeneration by inducing more neurons to return to embryonic patterns of tau gene expression.<\/jats:p>","DOI":"10.1177\/147323001003800513","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1682-1688","source":"Crossref","is-referenced-by-count":9,"title":["Local Delivery of Recombinant Human Bone Morphogenetic Protein-2 Increases Axonal Regeneration and the Expression of Tau Protein after Facial Nerve Injury"],"prefix":"10.1177","volume":"38","author":[{"given":"G","family":"Wu","sequence":"first","affiliation":[{"name":"School of Stomatology, The Fourth Military Medical University, Xi'an, China"},{"name":"School and Hospital of Stomatology, The Wenzhou Medical College, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Zhu","sequence":"additional","affiliation":[{"name":"School and 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