{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:25:01Z","timestamp":1792383901909,"version":"4.4.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>This study investigated the relative accuracy and roles of abdominal ultrasonography, hepatobiliary scintigraphy and liver biopsy in the diagnosis of infantile cholestasis. A total of 50 infants (27 females) aged 1 \u2212 12 months were classified into those with intrahepatic causes of cholestasis ( n = 22) and those with extrahepatic causes ( n = 28). Cholestasis is caused by a wide range of conditions and diagnosis requires meticulous history taking, thorough clinical examination and many laboratory tests. The most common cause of intrahepatic cholestasis was found to be idiopathic neonatal hepatitis (54.5%), followed by infectious hepatitis (9.1%), metabolic liver diseases (9.1%), intrahepatic biliary atresia (9.1%) and Alagille syndrome (4.5%). The most common cause of extrahepatic cholestasis was extrahepatic biliary atresia (96.4%). The incidence of choledochal cyst was low (3.6%). The cornerstone of the diagnosis of infantile cholestasis was found to be liver biopsy, which was associated with a high degree of accuracy.<\/jats:p>","DOI":"10.1177\/147323001003800626","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"2100-2116","source":"Crossref","is-referenced-by-count":12,"title":["Predictive Value of Assessment of Different Modalities in the Diagnosis of Infantile Cholestasis"],"prefix":"10.1177","volume":"38","author":[{"given":"AES","family":"Donia","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SM","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine, Misr University for Science and Technology (MUST), 6th of October City, 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