{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:43:29Z","timestamp":1777725809784,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>\n                    This report presents a case of nasopharyngeal diffuse large B-cell lymphoma and a literature review concerning the use of [\n                    <jats:sup>18<\/jats:sup>\n                    F]fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT). A 37-year old man was admitted to hospital complaining of nasal secretions with minor epistaxis and a 20-year history of snoring. Nasal endoscopy found diffuse swelling in the nasopharynx and a biopsy was performed. Prior to chemotherapy, FDG-PET\/CT showed soft-tissue diffuse thickening and FDG accumulation in the nasopharynx and bilateral cervical lymph nodes; FDG did not accumulate elsewhere. After four cycles of chemotherapy (rituximab, cyclo-phosphamide, doxorubicin, vincristine) and prednisone treatment, FDG-PET\/CT showed that FDG still accumulated in the nasopharynx and bilateral cervical lymph nodes, therefore radiotherapy was initiated. At 1 year, FDG-PET\/CT showed no FDG accumulation. Immunohistochemical analysis revealed that the tumour was positive for phosphorylated protein kinase B (Akt), suggesting that FDG uptake may be associated with factors activated by the phosphatidylinositol 3-kinase\/Akt signalling pathway.\n                  <\/jats:p>","DOI":"10.1177\/147323001003800632","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"2160-2168","source":"Crossref","is-referenced-by-count":10,"title":["Expression of Glucose Transporter-1, Hypoxia-Inducible Factor-1\u03b1, Phosphatidylinositol 3-Kinase and Protein Kinase B (Akt) in Relation to [\n                    <sup>18<\/sup>\n                    F]Fluorodeoxyglucose Uptake in Nasopharyngeal Diffuse Large B-Cell Lymphoma: A Case Report and Literature Review"],"prefix":"10.1177","volume":"38","author":[{"given":"J","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X-M","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-T","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-H","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L-X","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, The First 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