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This prospective study analysed the effects of proinflammatory cytokine gene polymorphisms (tumour necrosis factor-\u03b1 [TNFA] 308G&gt;A and interleukin-6 [IL6] 174G&gt;C) and prothrombotic factor gene mutations (prothrombin G20210A, factor V Leiden G1691A and methylenetetrahydrofolate reductase [MTHFR] C677T) on the early neurological prognosis in 40 term hypoxic ischaemic encephalopathic neonates. There were significant relationships for Sarnat and Sarnat staging with electroencephalographic findings, transfontanelle ultrasound (US) results, early neonatal outcome and neurological morbidity. Genetic mutations in the prothrombotic proteins, the TNFA 308G&gt;A polymorphism and the cerebrospinal fluid levels of TNF-\u03b1 protein were not related to clinical stage, electroencephalography, transfontanelle US or neurological status at discharge or at postnatal months 6 and 12. The IL6 174GC genotype demonstrated a protective role, being significantly correlated with normal electroencephalography, transfontanelle US and normal neurological findings at discharge. In conclusion, the IL6 174GC gene polymorphism seems to play a role in determining the risk and\/or severity of perinatal cerebral injury.<\/jats:p>","DOI":"10.1177\/147323001103900517","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1744-1756","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Genetic Factors that Influence Short-Term Neurodevelopmental Outcome in Term Hypoxic-Ischaemic Encephalopathic Neonates"],"prefix":"10.1177","volume":"39","author":[{"given":"S","family":"Calkavur","sequence":"first","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Akisu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Olukman","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Dr Beh\u00e7et Uz Children's Hospital, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Balim","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Berdeli","sequence":"additional","affiliation":[{"name":"Molecular Genetics Laboratory, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Cakmak","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Koroglu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Yalaz","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kultursay","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,10,1]]},"reference":[{"key":"bibr1-147323001103900517","first-page":"867","volume-title":"Neonatal-Perinatal Medicine, Disease of the Fetus and Infant","author":"Vanucci RC","year":"2002","edition":"6"},{"key":"bibr2-147323001103900517","first-page":"279","volume-title":"Neurology of the Newborn","author":"Volpe JJ","year":"1995","edition":"3"},{"key":"bibr3-147323001103900517","first-page":"1384","volume-title":"Avery's Neonatology Pathophysiology & Management of the Newborn","author":"Hill A","year":"2005","edition":"6"},{"key":"bibr4-147323001103900517","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000156477.00386.E7"},{"key":"bibr5-147323001103900517","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.10.2437"},{"key":"bibr6-147323001103900517","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.11.022"},{"key":"bibr7-147323001103900517","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000144819.45689.BB"},{"key":"bibr8-147323001103900517","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199806000-00006"},{"key":"bibr9-147323001103900517","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1542\/peds.98.1.141","volume":"98","author":"Use and abuse of the Apgar Score","year":"1996","journal-title":"Pediatrics"},{"key":"bibr10-147323001103900517","first-page":"309","volume":"1","author":"ACOG Committee Opinion: Inappropriate uses of the terms fetal distress and birth asphyxia. 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