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This study measured levels of \u03b1-cleaved soluble APP (\u03b1sAPP) and \u03b2-amyloid 42 (A\u03b242) in the cerebrospinal fluid (CSF) of 42 MS, 10 neuromyelitis optica and 25 clinically isolated syndrome patients and 21 healthy controls, and analysed the correlation between \u03b1sAPP and A\u03b242 levels and relevant clinical parameters. The CSF concentrations of \u03b1sAPP and A\u03b242 in patients and controls were not significantly different. There was a significant inverse correlation in patients between CSF asAPP concentration and the Expanded Disability Status Scale (EDSS), but no significant correlation between CSF A\u03b242 concentration and EDSS. The concentration of \u03b1sAPP in the CSF of statin-treated patients was significantly higher than in those not treated with statins, suggesting that statins may have a neuroprotective effect. In conclusion, \u03b1sAPP was present at similar levels in the CSF of patients with neuromyelitis optica, MS and clinically isolated syndrome and healthy controls, and an inverse correlation existed between CSF \u03b1sAPP concentration and neurological disability.<\/jats:p>","DOI":"10.1177\/147323001103900641","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"2402-2413","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Cerebrospinal Fluid Levels of Soluble Amyloid Precursor Protein and \u03b2-Amyloid 42 in Patients with Multiple Sclerosis, Neuromyelitis Optica and Clinically Isolated Syndrome"],"prefix":"10.1177","volume":"39","author":[{"given":"W","family":"Mai","sequence":"first","affiliation":[{"name":"Department of Neurology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, 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