{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:48:50Z","timestamp":1777726130707,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>OBJECTIVE: To investigate the usefulness of diffusion-weighted imaging (DWI)-guided, single-voxel proton magnetic resonance spectroscopy (SVS) for preoperative evaluation of cerebral glioma grade. METHODS: For SVS, placement of volume-of-interest was guided by the minimal apparent diffusion coefficient value obtained from DWI. Spectral data for N-acetylaspartate (NAA), choline (Cho), and phosphocreatine (Cr) were analysed in 33 patients with primary gliomas. RESULTS: Cho\/Cr and Cho\/NAA ratios were significantly higher in high-grade than in low-grade gliomas; NAA\/Cr ratios were significantly lower in high-grade than in low-grade gliomas. Receiver operating characteristic curve analysis demonstrated a threshold value of 2.01 for Cho\/Cr for sensitivity, specificity, positive predictive and negative predictive values of 86.36%, 90.00%, 95.00% and 75.00%, respectively. Threshold values of 2.49 and 0.97 were obtained for Cho\/NAA and NAA\/Cr, respectively. Despite no significant difference in diagnostic accuracy between the metabolite ratios, diagnostic accuracy using the Cho\/Cr ratio was slightly better than that of Cho\/NAA or NAA\/Cr. CONCLUSION: DWI-guided SVS has potential value for the preoperative prediction of glioma grade.<\/jats:p>","DOI":"10.1177\/147323001204000108","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"76-84","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Noninvasive Evaluation of Cerebral Glioma Grade by Using Diffusion-Weighted Imaging-Guided Single-Voxel Proton Magnetic Resonance Spectroscopy"],"prefix":"10.1177","volume":"40","author":[{"given":"Z-L","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology, Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q-S","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C-F","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"bibr1-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.174.2.2153310"},{"key":"bibr2-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-001-0760-0"},{"key":"bibr3-147323001204000108","first-page":"1989","volume":"24","author":"Law M","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr4-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2432060493"},{"key":"bibr5-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1007\/BF00598951"},{"key":"bibr6-147323001204000108","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.4.0533"},{"key":"bibr7-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.3.r99jn46791"},{"key":"bibr8-147323001204000108","first-page":"117","volume":"20","author":"Meyerand ME","year":"1999","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr9-147323001204000108","first-page":"225","volume":"24","author":"Bulakbasi N","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr10-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006431120031"},{"key":"bibr11-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200411000-00003"},{"key":"bibr12-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2393042031"},{"key":"bibr13-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1080\/02841850600580598"},{"key":"bibr14-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2413051276"},{"key":"bibr15-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2513080899"},{"key":"bibr16-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.02.004"},{"key":"bibr17-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(02)00305-4"},{"key":"bibr18-147323001204000108","first-page":"1362","volume":"27","author":"Rumboldt Z","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr19-147323001204000108","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0842"},{"key":"bibr20-147323001204000108","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.4.0794"},{"key":"bibr21-147323001204000108","first-page":"3","volume":"13","author":"Yerli H","year":"2007","journal-title":"Diagn Interv Radiol"},{"key":"bibr22-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2382041896"},{"key":"bibr23-147323001204000108","first-page":"1412","volume":"27","author":"Kim JH","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr24-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2008.07.002"},{"key":"bibr25-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2004.03.011"},{"key":"bibr26-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0253-x"},{"key":"bibr27-147323001204000108","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2007.12.006"},{"key":"bibr28-147323001204000108","first-page":"659","volume":"21","author":"Shimizu H","year":"2000","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323001204000108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323001204000108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:45:12Z","timestamp":1777459512000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323001204000108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1177\/147323001204000108"],"URL":"https:\/\/doi.org\/10.1177\/147323001204000108","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}