{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:49:24Z","timestamp":1777726164943,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>OBJECTIVE: The association between codon 72 polymorphism of the tumour protein p53 ( TP53) gene \u2014 which results in a mis-sense mutation of arginine (R) to proline (P) \u2013 and susceptibility to hepatocellular carcinoma (HCC) is controversial. A meta-analysis was performed in order to define this relationship more precisely. METHODS: Published studies of TP53 codon 72 polymorphism and the risk of HCC were identified. Data were extracted, and summary odds ratios (OR) and 95% confidence intervals (95% CI) were calculated. Pooled ORs were determined for an additive model (R\/R versus P\/P), a dominant model ([R\/R + R\/P] versus P\/P) and a recessive model (R\/R versus [R\/P + P\/P]). RESULTS: The meta-analysis included seven case\u2014control studies (total 1511 cases and 2165 controls). The risk of cancer was significantly decreased in the overall dominant model and the dominant model in Asian populations. A significantly decreased risk was found for all models in hospital-based but not population-based studies. There was no association between polymorphism and cancer risk when data were stratified according to hepatitis B or C virus infection status. CONCLUSION: The TP53 codon 72 polymorphism may be a risk factor for HCC.<\/jats:p>","DOI":"10.1177\/147323001204000206","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"446-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>TP53<\/i>\n                    Codon 72 Polymorphism with Hepatocellular Carcinoma: A Meta-Analysis"],"prefix":"10.1177","volume":"40","author":[{"given":"C","family":"Ding","sequence":"first","affiliation":[{"name":"The Fourth Department of General Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Yu","sequence":"additional","affiliation":[{"name":"The Department of Radiation Oncology, The Second Affiliated Hospital, Harbin Medical University, Harbin, 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