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METHODS: A retrospective analysis was performed on 817 high-risk HPV-infected women with histologically verified CIN 1 or normal cervical histology. Patients were followed-up for a maximum of 24 months. Cervical HPV DNA tests were performed at every visit. RESULTS: At the end of follow-up, 648\/817 (79.3%) patients were free from HPV infection and 66\/817 patients (8.1%) progressed to CIN 2 or higher. Age, parity, cytology and viral load at diagnosis were significantly and inversely associated with HPV clearance. Cytology, viral load and presence of CIN 1 lesions were significantly associated with lesion progression. CONCLUSIONS: Cytology and high-risk HPV viral load may be useful markers for the likelihood of high-risk HPV clearance and lesion progression. Histological status, parity and marital status may also be useful factors to consider when predicting progression.<\/jats:p>","DOI":"10.1177\/147323001204000210","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"486-496","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Factors Affecting the Clearance of High-Risk Human Papillomavirus Infection and the Progression of Cervical Intraepithelial Neoplasia"],"prefix":"10.1177","volume":"40","author":[{"given":"JW","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Korea University Guro Hospital"},{"name":"Department of Ostetrics and Gynaecology, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Republic of 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