{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:49:48Z","timestamp":1777726188078,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    OBJECTIVE: This study investigated the effects of ezetimibe, an inhibitor of intestinal cholesterol absorption, on early phase diabetic nephropathy. METHODS: A total of 32 hypercholesterolaemic type 2 diabetes patients with microalbuminuria, defined as a urinary albumin excretion (UAE) \u2265 30 but &lt; 300 mg\/g creatinine, were enrolled. Various clinical and laboratory parameters were determined at baseline and after 6 months of treatment with 10 mg\/day ezetimibe. RESULTS: Ezetimibe treatment significantly decreased glycated haemoglobin (HbA\n                    <jats:sub>1c<\/jats:sub>\n                    ), low-density lipoprotein-cholesterol (LDL-C), triglycerides and UAE, and significantly increased high-density lipoprotein-cholesterol and albumin. It also decreased the serum level of monocyte chemoattractant protein-1 (MCP-1), but this difference was not statistically significant. Univariate analyses showed a correlation between UAE and body mass index, systolic and diastolic blood pressures, HbA\n                    <jats:sub>1c<\/jats:sub>\n                    , LDL-C, estimated glomerular filtration rate (inverse), creatinine and MCP-1. Since these parameters may be closely correlated with each other, multiple stepwise regression analysis was performed and demonstrated that HbA\n                    <jats:sub>1c<\/jats:sub>\n                    and MCP-1 were independent determinants of UAE. CONCLUSIONS: Ezetimibe may be a promising therapeutic strategy for improving albumin excretion, partly through its anti-inflammatory properties, and for reducing LDL-C in hypercholesterolaemic type 2 diabetes patients with microalbuminuria.\n                  <\/jats:p>","DOI":"10.1177\/147323001204000246","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"798-803","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Ezetimibe Reduces Urinary Albumin Excretion in Hypercholesterolaemic Type 2 Diabetes Patients with Microalbuminuria"],"prefix":"10.1177","volume":"40","author":[{"given":"T","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Amaha","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kawagoe","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Keio University School of Medicine, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SI","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"key":"bibr1-147323001204000246","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00712.x"},{"key":"bibr2-147323001204000246","doi-asserted-by":"publisher","DOI":"10.2174\/138161206776389796"},{"key":"bibr3-147323001204000246","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.03.022"},{"key":"bibr4-147323001204000246","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.11.2728"},{"key":"bibr5-147323001204000246","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.04.011"},{"key":"bibr6-147323001204000246","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.766"},{"key":"bibr7-147323001204000246","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1136\/pgmj.69.807.12","volume":"69","author":"Laker MF","year":"1993","journal-title":"Postgrad Med 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