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METHODS: Using microarray technology and bioinformatics analyses the underlying molecular mechanism of action of CDX was evaluated by constructing gene regulation and protein\u2014protein interaction coexpression networks. RESULTS: CDX treatment induced a large number of related genes at the transcriptional level. The MYC gene (v-myc myelocytomatosis viral oncogene homologue [avian]) had a key role in the response of Hs683 cells to CDX treatment. Activation of MYC upregulated NDRG1 (N-myc downstream regulated 1), WNT10B (wingless-type mouse mammary tumour virus integration site family, member 10B), CASP9 (caspase 9, apoptosis-related cysteine peptidase) and CDKN2A (cyclin-dependent kinase inhibitor 2A), and downregulated ID3 (inhibitor of DNA binding 3, dominant negative helix\u2014loop\u2014helix protein) and SLC1A4 (solute carrier family 1 [glutamate\/neutral amino acid transporter], member 4). In addition, a subnetwork was constructed among SPP1 (secreted phosphoprotein 1), SDC1 (syndecan 1) and CD44 based on protein\u2014protein interactions, and these genes were predicted to be involved in glioma cell invasion. CONCLUSION: These findings might provide novel therapeutic targets for glioma chemotherapy.<\/jats:p>","DOI":"10.1177\/147323001204000307","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"887-898","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcriptome and Coexpression Network Analysis of the Human Glioma Cell Line Hs683 Exposed to Candoxin"],"prefix":"10.1177","volume":"40","author":[{"given":"Yx","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 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