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METHODS: Male Sprague Dawley rats were randomly divided into four groups ( n = 15\/group): sham operated controls (group A); focal cerebral ischaemia (group B); vascular dementia (group C); and vascular dementia treated with 20 mg\/kg nimodipine daily (group D). The Morris water maze test evaluated learning and memory, and magnetic resonance perfusion-weighted imaging was used to measure rCBF. Hippocampal levels of nuclear factor-\u03baB (NF-\u03baB), tumour necrosis factor-\u03b1 (TNF-\u03b1) and interleukin 1\u03b2 (IL-1\u03b2) were measured. RESULTS: Compared with group C, rats in group D demonstrated significantly improved learning ability and significantly increased hippocampal rCBF. The levels of NF-\u03baB, TNF-\u03b1 and IL-1\u03b2 were significantly lower in group D than in group C. Hippocampal nerve cell morphology was abnormal in group C but near normal in group D. CONCLUSIONS: Nimodipine improved the symptoms of cognitive impairment, increased rCBF, reduced hippocampal cytokine levels and alleviated neuronal injury in the hippocampus of rats with experimental vascular dementia.<\/jats:p>","DOI":"10.1177\/147323001204000322","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1036-1045","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Nimodipine Improves Regional Cerebral Blood Flow and Suppresses Inflammatory Factors in the Hippocampus of Rats with Vascular Dementia"],"prefix":"10.1177","volume":"40","author":[{"given":"X-L","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, First Affiliated Hospital of Liaoning Medical College, Jinzhou, Liaoning Province, 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