{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:12:10Z","timestamp":1782601930922,"version":"3.54.5"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>OBJECTIVES: To evaluate the efficacy of treatments for aqueous misdirection syndrome and explore possible risk factors influencing prognosis. METHODS: Data including demographics, initial clinical characteristics and ocular outcomes at follow-up were collected for patients treated for aqueous misdirection syndrome. Main outcome measures were: best-corrected visual acuity (BCVA); intraocular pressure (IOP); number of antiglaucoma medications; recurrence; complications. RESULTS: Data were available for 50 patients (57 eyes). Final mean BCVA improved significantly and correlated with baseline BCVA (mean follow-up, 34.47 \u00b1 28.65 months). Final mean IOP and mean number of antiglaucoma medications were significantly reduced. Treatment failure rates were higher in patients with significantly higher IOP at baseline and\/or shorter axial length. Following pars plana vitrectomy (PPV), recurrence occurred in two of 10 pseudophakic and one of 40 phakic eyes; complications were observed in 12\/50 eyes (choroidal detachment, corneal decompensation, retinal detachment, vitreous haemorrhage, hyphaema). CONCLUSIONS: PPV and laser treatments, augmented by pharmacotherapy, were effective in treating aqueous misdirection syndrome. Surgical intervention should be undertaken early in eyes with higher baseline IOP and\/or shorter axial length. Total vitrectomy\u2014 zonulectomy\u2014iridectomy is a potential approach for recalcitrant cases.<\/jats:p>","DOI":"10.1177\/147323001204000437","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1568-1579","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Analysis of 50 Chinese Patients with Aqueous Misdirection Syndrome: A Retrospective Hospital-Based Study"],"prefix":"10.1177","volume":"40","author":[{"given":"C","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"bibr1-147323001204000437","first-page":"108","volume":"15","author":"Von Graefe A","year":"1869","journal-title":"Arch Ophthalmol"},{"key":"bibr2-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1972.01000020708018"},{"key":"bibr3-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-004-1038-9"},{"key":"bibr4-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1972.01000020499002"},{"key":"bibr5-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00405-5"},{"key":"bibr6-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90135-2"},{"key":"bibr7-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31913-X"},{"key":"bibr8-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76951-X"},{"key":"bibr9-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.73.8.617"},{"key":"bibr10-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(02)01213-0"},{"key":"bibr11-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040056006"},{"key":"bibr12-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060050053036"},{"key":"bibr13-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199201020-00010"},{"key":"bibr14-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(87)90101-9"},{"key":"bibr15-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200304000-00013"},{"key":"bibr16-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00642-4"},{"key":"bibr17-147323001204000437","volume-title":"Becker\u2013 Shaffer's Diagnosis and Therapy of the Glaucomas","author":"Becker B","year":"1999","edition":"7"},{"key":"bibr18-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1763-0"},{"key":"bibr19-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1993.21"},{"key":"bibr20-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(87)90347-3"},{"key":"bibr21-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.05.026"},{"key":"bibr22-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.04.031"},{"key":"bibr23-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.02.009"},{"key":"bibr24-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.2.163"},{"key":"bibr25-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2003.07.009"},{"key":"bibr26-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140275003"},{"key":"bibr27-147323001204000437","first-page":"73","volume":"27","author":"Momoeda S","year":"1983","journal-title":"Jpn J Ophthalmol"},{"key":"bibr28-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1997.176"},{"key":"bibr29-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30870-6"},{"key":"bibr30-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-198102110-00013"},{"key":"bibr31-147323001204000437","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.6.808"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323001204000437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323001204000437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:45:53Z","timestamp":1777459553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323001204000437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1177\/147323001204000437"],"URL":"https:\/\/doi.org\/10.1177\/147323001204000437","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}