{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:24:17Z","timestamp":1793683457228,"version":"4.5.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Hospital del Mar"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cardiovascular Nursing"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background and aims:<\/jats:title><jats:p> Lack of achievement of secondary prevention objectives in patients with ischaemic heart disease remains an unmet need in this patient population. We aimed at evaluating the six-month efficacy of an intensive lipid-lowering intervention, coordinated by nurses and implemented after hospital discharge, in patients hospitalized for an ischaemic heart disease event. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Randomized controlled trial, in which a nurse-led intervention including periodic follow-up, serial lipid level controls, and subsequent optimization of lipid-lowering therapy, if appropriate, was compared with standard of care alone in terms of serum lipid-level control at six months after discharge. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The nurse-led intervention was associated with an improved management of low-density lipoprotein (LDL) cholesterol levels compared with standard of care alone: LDL cholesterol levels \u2a7d100 mg\/dL were achieved in 97% participants in the intervention arm as compared with 67% in the usual care arm ( p value &lt;0.001), the LDL cholesterol \u2a7d70 mg\/dL target recommended by the 2016 European Society of Cardiology guidelines was achieved in 62% vs. 37% participants ( p value 0.047) and the LDL cholesterol reduction of \u2a7e50% recommended by the American College of Cardiology\/American Heart Association in 2013 was achieved in 25.6% of participants in the intervention arm as compared with 2.6% in the usual care arm ( p value 0.007). The intervention was also associated with improved blood pressure control among individuals with hypertension. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Our findings highlight the opportunity that nurse-led, intensive, post-discharge follow-up plans may represent for achieving LDL cholesterol guideline-recommended management objectives in patients with ischaemic heart disease. These findings should be replicated in larger cohorts. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1474515119831511","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T22:09:58Z","timestamp":1550095798000},"page":"366-374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of a nurse-led lipid-lowering secondary prevention intervention in patients hospitalized for ischemic heart disease: A pilot randomized controlled trial"],"prefix":"10.1093","volume":"18","author":[{"given":"Sonia","family":"Ruiz-Bustillo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, Barcelona, Spain"},{"name":"Departament of Medicine, Autonomous University of Barcelona, Spain"},{"name":"Biomedical Research Group (GREC), Hospital del Mar Biomedical Research Institute (IMIM), Barcelona, 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