{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:23:33Z","timestamp":1777940613036,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Tenofovir disoproxil fumarate was the first nucleotide analogue reverse transcriptase inhibitor to be approved for treatment of human immunodeficiency virus infection. It is a relatively safe drug but can present with nephrotoxicity. We report a case of 36-year-old male who presented with acute onset flaccid paraparesis. He was a diagnosed case of acquired immunodeficiency syndrome for 9 years ago and was on tenofovir-based antiretroviral therapy for last 6 months. As the patient had normal anion gap metabolic acidosis, hypokalaemia and urine pH &gt; 5.5, distal renal tubular acidosis (RTA) was suspected. He improved dramatically within 24 h of hospitalisation after potassium correction to regain normal power. Tenofovir-induced distal RTA presenting as hypokalaemic paralysis is a very rare complication of tenofovir; hence, we are reporting this case. In addition, we suggest regular follow-up of patients taking tenofovir with urine analysis and serum potassium to detect this complication earlier as it is reversible.<\/jats:p>","DOI":"10.1177\/14782715221103643","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T08:53:13Z","timestamp":1655455993000},"page":"117-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Tenofovir-induced distal renal tubular acidosis: A rare cause of recurrent hypokalaemic paralysis"],"prefix":"10.1177","volume":"52","author":[{"given":"Mahesh","family":"Dave","sequence":"first","affiliation":[{"name":"Department of Medicine, RNT Medical College, Udaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manasvin","family":"Sareen","sequence":"additional","affiliation":[{"name":"Department of Medicine, RNT Medical College, Udaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuj","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Medicine, RNT Medical College, Udaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagaraj T","family":"Gonchikar","sequence":"additional","affiliation":[{"name":"Department of Medicine, RNT Medical College, Udaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yash","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, RNT Medical College, Udaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"bibr1-14782715221103643","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051871"},{"key":"bibr2-14782715221103643","doi-asserted-by":"publisher","DOI":"10.1086\/499048"},{"key":"bibr3-14782715221103643","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct258"},{"key":"bibr4-14782715221103643","volume":"16","author":"Szczech LA","year":"2008","journal-title":"Top HIV Med"},{"key":"bibr5-14782715221103643","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2007.04.008"},{"key":"bibr6-14782715221103643","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-015-0132-1"},{"key":"bibr7-14782715221103643","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-016-0100-y"},{"key":"bibr8-14782715221103643","unstructured":"Who-umc.org and The Uppsala Monitoring Centre. 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