{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:23:36Z","timestamp":1777940616265,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Calcinosis universalis (CU) is characterised by diffuse deposition of insoluble calcium salt in the skin, subcutaneous tissue or organs. Calcium deposits in the breast may be associated with an increased risk for developing breast cancer. We present a case of a 65-year-old woman diagnosed with CU secondary to undifferentiated connective tissue disease. She developed progressive calcification of her skin, which did not improve with oral medications aimed at reducing the calcification. Investigations to look for possible causes of calcification were all unremarkable. During follow-up, calcification was also found in both her breasts. Initial mammography was reported as fibroadenoma. However, 3 years later, she returned with metastatic breast cancer which presented with a massive pleural effusion of the right lung. Calcinosis universalis should now be considered as a risk factor for breast cancer.<\/jats:p>","DOI":"10.1177\/14782715221104860","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T09:10:21Z","timestamp":1655802621000},"page":"134-137","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Calcinosis universalis and breast cancer: A distinctive association"],"prefix":"10.1177","volume":"52","author":[{"given":"Abu Mansor Matardiah","family":"Nor Hashimah","sequence":"first","affiliation":[{"name":"Department of Medicine, Rheumatology Unit, Hospital Pulau Pinang, George Town, Pinang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sow Lai","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rheumatology Unit, Hospital Pulau Pinang, George Town, Pinang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azman Ali","family":"Raymond","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"bibr1-14782715221104860","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.038"},{"key":"bibr2-14782715221104860","volume":"2012","author":"Suleman FE","journal-title":"SA J Radiol"},{"key":"bibr3-14782715221104860","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.181.6.1811679"},{"key":"bibr4-14782715221104860","volume":"9","author":"Thomas RH","year":"1984","journal-title":"J Hand Surg"},{"key":"bibr5-14782715221104860","doi-asserted-by":"publisher","DOI":"10.1002\/art.22158"},{"key":"bibr6-14782715221104860","volume":"39","author":"Touart DM","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"bibr7-14782715221104860","volume":"5","author":"Fuchs D","year":"1986","journal-title":"Clin Rheumatol"},{"key":"bibr8-14782715221104860","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.6.576"},{"key":"bibr9-14782715221104860","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780381117"},{"key":"bibr10-14782715221104860","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken074"},{"key":"bibr11-14782715221104860","volume":"28","author":"Marco Puche A","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"bibr12-14782715221104860","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-37186-2","volume":"9","author":"Ali MCK","year":"2019","journal-title":"Sci Rep"},{"key":"bibr13-14782715221104860","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2016.05.012"},{"key":"bibr14-14782715221104860","volume":"12","author":"Castronovo V","year":"1998","journal-title":"Int J Oncol"},{"key":"bibr15-14782715221104860","doi-asserted-by":"publisher","DOI":"10.1002\/mc.1070"},{"key":"bibr16-14782715221104860","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4527-7"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715221104860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14782715221104860","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715221104860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:55:34Z","timestamp":1777701334000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14782715221104860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1177\/14782715221104860"],"URL":"https:\/\/doi.org\/10.1177\/14782715221104860","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}