{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:23:38Z","timestamp":1777940618660,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Negative-pressure wound therapy has been shown to be effective in re-epithelialisation in recalcitrant pyoderma gangrenosum. This case documents a patient whose co-morbidities limited the standard treatment options and required an alternative management plan. The STOP GAP randomised control trial found that both oral prednisolone and ciclosporin were equally effective in the treatment of pyoderma gangrenosum. However, in this case, the patient had type 2 diabetes and prednisolone resulted in persistently elevated blood glucose levels. Lower doses were ineffective and it was subsequently stopped once other treatments showed a clinical improvement. A recent diagnosis of breast cancer prevented the use of ciclosporin and other immunosuppressive treatments. After multidisciplinary discussion, involving breast surgeons, oncology, dermatology and tissue viability, doxycycline was commenced alongside a portable negative-pressure device with twice weekly tissue viability input. The introduction of this device resulted in a rapid reduction in the wound size and facilitated healing with an excellent outcome.<\/jats:p>","DOI":"10.1177\/14782715221126768","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T02:47:41Z","timestamp":1663296461000},"page":"260-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Negative-pressure wound therapy as an adjunct to treating pyoderma gangrenosum"],"prefix":"10.1177","volume":"52","author":[{"given":"Orlagh","family":"Mulholland","sequence":"first","affiliation":[{"name":"Department of Dermatology, Belfast City Hospital, Belfast, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Middleton","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Belfast City Hospital, Belfast, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Belfast City Hospital, Belfast, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"bibr1-14782715221126768","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2958"},{"key":"bibr2-14782715221126768","unstructured":"Schmieder SJ, Krishnamurthy K. Pyoderma Gangrenosum. 2020 Jul 10. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2020."},{"key":"bibr3-14782715221126768","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0213-x"},{"key":"bibr4-14782715221126768","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13466"},{"key":"bibr5-14782715221126768","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.009"},{"key":"bibr6-14782715221126768","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14180"},{"key":"bibr7-14782715221126768","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.10.1249"},{"key":"bibr8-14782715221126768","volume":"32","author":"Woelfel SL","year":"2020","journal-title":"Wounds"},{"key":"bibr9-14782715221126768","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.922581"},{"key":"bibr10-14782715221126768","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.07.030"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715221126768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14782715221126768","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715221126768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:55:44Z","timestamp":1777701344000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14782715221126768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1177\/14782715221126768"],"URL":"https:\/\/doi.org\/10.1177\/14782715221126768","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}