{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:35:25Z","timestamp":1782902125009,"version":"3.54.5"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2022,12]]},"abstract":"\n Background:<\/jats:title>\n Proton pump inhibitors (PPIs) are extensively prescribed but may cause photosensitivity and drug-induced lupus erythematosus (DILE), which can be overlooked as the drug may have been taken for years prior to presentation.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We reviewed the clinical and investigation findings of patients diagnosed with PPI-induced photosensitivity, diagnosed through the Scottish Photobiology Service.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n We report 11 patients with median age of onset 61-years and mean duration of PPI ingestion of 5-years [DILE ( n\u2009=\u20096), phototoxicity ( n\u2009=\u20093) and drug-induced solar urticaria through a lupus mechanism ( n\u2009=\u20092)]. Five had Anti-Ro antibodies (three also ANA positive). Predominantly UVA and visible light photosensitivity was observed on phototesting.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n PPIs are a reversible cause of photosensitivity and DILE. Time to onset from drug initiation to symptoms can be prolonged, so clinicians should have a high index of suspicion in those taking PPIs. Most are diagnosed through clinical assessment and lupus serology, with phototesting indicated if there is diagnostic uncertainty.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/14782715221132858","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T04:47:30Z","timestamp":1666673250000},"page":"287-291","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Insights into proton pump inhibitor-induced photosensitivity: An observational study in a tertiary photobiology service"],"prefix":"10.1177","volume":"52","author":[{"given":"Sanaa","family":"Butt","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"McMullan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dawe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Ibbotson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"bibr1-14782715221132858","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12699"},{"key":"bibr2-14782715221132858","unstructured":"National Statistics. Prescriptions Dispensed in the Community \u2013 Statistics for England. Official statistics, National statistics. https:\/\/digital.nhs.uk\/data-and-information\/publications\/statistical\/prescriptions-dispensed-in-the-community\/prescriptions-dispensed-in-the-community-england\u20142007\u20142017"},{"key":"bibr3-14782715221132858","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2009.00391.x"},{"key":"bibr4-14782715221132858","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1973.tb02972.x"},{"key":"bibr5-14782715221132858","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"bibr6-14782715221132858","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328355b8d3"},{"key":"bibr7-14782715221132858","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322248"},{"key":"bibr8-14782715221132858","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-016-0067-4"},{"key":"bibr9-14782715221132858","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12583"},{"key":"bibr10-14782715221132858","doi-asserted-by":"publisher","DOI":"10.1039\/c8pp00011e"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715221132858","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14782715221132858","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715221132858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:55:49Z","timestamp":1777701349000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14782715221132858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1177\/14782715221132858"],"URL":"https:\/\/doi.org\/10.1177\/14782715221132858","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,25]]}}}