{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:25:38Z","timestamp":1781184338590,"version":"3.54.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Creutzfeldt-Jakob disease is a rare and incurable form of rapidly progressive neurodegenerative disease. The disease is fatal, and most patients die within 1 year of diagnosis. Clinical features include progressive cognitive dysfunction, delusions or hallucinations, cerebellar ataxia, myoclonus, visual disturbances, extrapyramidal signs and eventually akinetic mutism. Most patients present with varied clinical presentation, hence making it difficult to diagnose at an early stage. We report five cases of sporadic Creutzfeldt-Jakob disease presenting to a Tasmanian hospital in Australia over a period of 52 months. We highlight significant clinical features in all our patients including few atypical presentations, emphasise on relevant clinical biomarkers and illustrate characteristic abnormalities on electroencephalogram and neuroimaging.<\/jats:p>","DOI":"10.1177\/14782715221150580","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T01:53:40Z","timestamp":1674266020000},"page":"35-39","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Sporadic Creutzfeldt-Jakob disease in Northern Tasmania"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5511-0555","authenticated-orcid":false,"given":"Priyanka","family":"Rajalingam","sequence":"first","affiliation":[{"name":"Department of Medicine, Launceston General Hospital, Launceston, TAS, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Medicine, Launceston General Hospital, Launceston, TAS, Australia"},{"name":"Faculty of Medicine, Launceston Clinical School, University of Tasmania, Launceston, TAS, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lee-Archer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Launceston General Hospital, Launceston, TAS, Australia"},{"name":"Faculty of Medicine, Launceston Clinical School, University of Tasmania, Launceston, TAS, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Launceston General Hospital, Launceston, TAS, Australia"},{"name":"Faculty of Medicine, Launceston Clinical School, University of Tasmania, Launceston, TAS, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"bibr1-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2119323"},{"key":"bibr2-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30615-2"},{"key":"bibr3-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12355"},{"key":"bibr4-14782715221150580","unstructured":"Creutzfeldt-Jakob. Disease International Surveillance Network. Diagnostic criteria for surveillance of CJD, https:\/\/www.eurocjd.ed.ac.uk\/node\/833 (2017, accessed 9 July 2022)."},{"key":"bibr5-14782715221150580","doi-asserted-by":"publisher","DOI":"10.17265\/2159-5313\/2016.09.003"},{"key":"bibr6-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1007\/BF02892896"},{"key":"bibr7-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.074856"},{"key":"bibr8-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2007.19.4.428"},{"key":"bibr9-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20568"},{"key":"bibr10-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.197962"},{"key":"bibr11-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2018-001935"},{"key":"bibr12-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.12.007"},{"key":"bibr13-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20261"},{"key":"bibr14-14782715221150580","volume":"38","author":"Furlan AJ","journal-title":"Arch Neurol"},{"key":"bibr15-14782715221150580","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000134555.59460.5D"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715221150580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14782715221150580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715221150580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:56:06Z","timestamp":1777701366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14782715221150580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/14782715221150580"],"URL":"https:\/\/doi.org\/10.1177\/14782715221150580","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]}}}