{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:24:06Z","timestamp":1777940646931,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>Infection is a rare cause of panhypopituitarism and has not been reported in the context of Lemierre\u2019s syndrome. We present the case of a previously well 19-year-old man, who presented acutely unwell with meningitis and sepsis. Fusobacterium necrophorum was isolated from peripheral blood cultures and identified on cerebrospinal fluid with 16S rDNA Polymerase Chain Reaction (PCR). Imaging demonstrated internal jugular vein thrombosis with subsequent cavernous venous sinus thrombosis. Pituitary function tests were suggestive of panhypopituitarism. The patient was diagnosed with Lemierre\u2019s syndrome complicated by meningitis, cavernous sinus thrombosis, base of skull osteomyelitis, ischaemic stroke and panhypopituitarism. He was treated with 13\u2009weeks of intravenous antibiotics followed by 3\u2009weeks of oral amoxicillin, and anticoagulated with dalteparin then apixaban. His panhypopituitarism was managed with hydrocortisone, levothyroxine and desmopressin.<\/jats:p>","DOI":"10.1177\/14782715231198180","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T08:21:01Z","timestamp":1694074861000},"page":"258-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of Lemierre\u2019s syndrome causing panhypopituitarism, cavernous sinus thrombosis, ischaemic stroke and pulmonary embolism"],"prefix":"10.1177","volume":"53","author":[{"given":"Charlotte J","family":"Dewdney","sequence":"first","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes, NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Dewar","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fergus","family":"Doubal","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences, Edinburgh Neuroscience, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick R","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Princess Alexandra Eye Pavilion, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Subedi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus J","family":"Lyall","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes, NHS Lothian, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"bibr1-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)57035-4"},{"key":"bibr2-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-07"},{"key":"bibr3-14782715231198180","volume":"12","author":"Dasari SP","year":"2020","journal-title":"Cureus"},{"key":"bibr4-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2005.11.003"},{"key":"bibr5-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2020.03.027"},{"key":"bibr6-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2019-0110"},{"key":"bibr7-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-021-01156-1"},{"key":"bibr8-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-008-0496-4"},{"key":"bibr9-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-238521"},{"key":"bibr10-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-244669"},{"key":"bibr11-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2021-002928"},{"key":"bibr12-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70089-0"},{"key":"bibr13-14782715231198180","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1025-18"},{"key":"bibr14-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1186\/1865-1380-6-40"},{"key":"bibr15-14782715231198180","doi-asserted-by":"publisher","DOI":"10.1016\/0163-4453(91)92335-3"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715231198180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14782715231198180","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14782715231198180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:56:34Z","timestamp":1777701394000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14782715231198180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,7]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/14782715231198180"],"URL":"https:\/\/doi.org\/10.1177\/14782715231198180","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,7]]}}}