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Following initial infection, CMV typically becomes dormant but remains lifelong in the host. Reactivation of the latent virus can occur in many organ systems, including the gastrointestinal (GI) tract. Radiation proctitis is a known risk factor associated with prostate radiation, with complicating ulceration and GI bleeding. We present the first case report of an immunocompetent 81-year-old male with multiple episodes of life-threatening GI bleeding, secondary to a non-healing CMV-positive rectal ulcer and CMV colitis following radiation for prostate cancer. Multiple insults including prostate radiation, repeated blood transfusions and CMV infection likely contributed to the recurrent bleeding episodes.<\/jats:p>","DOI":"10.1177\/14782715231205916","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T04:19:35Z","timestamp":1698725975000},"page":"265-268","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiation proctitis with recurrent gastrointestinal bleeding complicated by cytomegalovirus"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-6247","authenticated-orcid":false,"given":"Austin B","family":"Auyeung","sequence":"first","affiliation":[{"name":"University of Central Florida College of Medicine, Graduate Medical Education\/HCA Florida North Florida Hospital, Internal Medicine Residency Program, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie N","family":"Rayan","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine, Graduate Medical Education\/HCA Florida North Florida Hospital, Internal Medicine Residency Program, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Tang","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine, Graduate Medical Education\/HCA Florida North Florida Hospital, Internal Medicine Residency Program, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanil","family":"Thomas","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, HCA Florida North Florida Hospital, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"bibr1-14782715231205916","first-page":"380","volume":"73","author":"Ledouble V","year":"2018","journal-title":"Rev Med Liege"},{"key":"bibr2-14782715231205916","unstructured":"Nwaokocha V, Clark B, Dworkin R. 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