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Although surgery is considered the primary treatment modality, it is often partially successful or unsuccessful. Moreover, these tumors frequently recur and may be resistant to conventional treatments, including surgery and radiotherapy. Therefore, early multimodal treatment and regular follow-up are necessary. We present a case of aggressive Cushing\u2019s disease managed with combined temozolomide therapy and radiotherapy following an unsuccessful transsphenoidal surgery, resulting in significant long-term radiological and biochemical remission. In addition, etomidate infusion was administered to achieve rapid cortisol reduction, highlighting its role as a bridging therapy to other modalities in treating life-threatening and severe hypercortisolemia outside an intensive care setting.<\/jats:p>","DOI":"10.1177\/14782715241293817","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T06:40:45Z","timestamp":1730270445000},"page":"304-309","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful management of refractory Cushing\u2019s disease with severe hypercortisolemia using etomidate and temozolomide in post-surgical failure"],"prefix":"10.1177","volume":"54","author":[{"given":"Neeti","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Medical College and Hospital, Kolkata, 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