{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:03:01Z","timestamp":1785855781445,"version":"3.56.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T00:00:00Z","timestamp":1256688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>BP control in diabetic patients is often poor. The contribution of secondary hypertension due to undiagnosed PA in hypertensive type 2 diabetic patients is not well studied. We prospectively screened 100 consecutive Asian type 2 diabetic patients with difficult-to-control or resistant hypertension for PA. PAC (pmol\/L) to PRA (ng\/mL\/h) ratio was measured; those with PAC-to-PRA ratio &gt;550 (corresponding PAC &gt;415) underwent intravenous 0.9% SLT. Patients with PAC \u2265140 following SLT had CT adrenals and bilateral AVS. Thirteen patients (13%) were confirmed to have PA, and all had resistant hypertension. Eight had a surgically correctable form of PA. Patients with PA had higher mean (SD) systolic [159.0 (10.6) vs. 146.0 (10.7) mmHg, p=0.001] and diastolic BP [94.6 (6.0) vs. 87.6 (5.9) mmHg, p=0.001], lower serum potassium [3.5 (0.6) vs. 4.3 (0.5) mmol\/L, p=0.001], and higher PAC [679.3 (291.0) vs. 239.5 (169.4) pmol\/L, p=0.001]. Identification and institution of definitive treatment for PA resulted in better BP control and in a reduction in the use of antihypertensive medications. Our findings demonstrate a high prevalence of PA in type 2 diabetic patients with resistant hypertension. Systematic screening for PA in this select group is recommended, as targeted treatment improves BP control.<\/jats:p>","DOI":"10.1177\/1479164109350556","type":"journal-article","created":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T20:59:29Z","timestamp":1256763569000},"page":"6-13","source":"Crossref","is-referenced-by-count":30,"title":["Type 2 diabetic patients with resistant hypertension should be screened for primary aldosteronism"],"prefix":"10.1177","volume":"7","author":[{"given":"J.J.","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"Khoo","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 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