{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:03:54Z","timestamp":1783487034965,"version":"3.55.0"},"reference-count":6,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Objective: To assess the effect of metformin administration on thyroid function in overweight women with polycystic ovarian syndrome (PCOS).<\/jats:p>\n                  <jats:p>Methods: Twenty-seven overweight women with PCOS and hypothyroidism were selected. Fifteen patients (group I) were treated with metformin 1500 mg\/day for 6 months and 12 patients (group II) with placebo. Serum thyrotropin (TSH), free T3 and free T4 were measured at baseline and 6 months after the beginning of the study.<\/jats:p>\n                  <jats:p>Results: A significant decrease ( p&lt;0.001) in TSH levels was observed in group I but not in group II subjects after 6 months of metformin treatment. No significant change in free T3 and free T4 was observed throughout the study in any group.<\/jats:p>\n                  <jats:p>Conclusion: In obese PCOS patients with primary hypothyroidism, metformin results in a significant fall and sometimes normalisation of TSH, without causing any reciprocal changes in other thyroid function parameters.<\/jats:p>","DOI":"10.1177\/1479164110391917","type":"journal-article","created":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T05:53:21Z","timestamp":1295848401000},"page":"47-48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism"],"prefix":"10.1177","volume":"8","author":[{"given":"S.","family":"Morteza Taghavi","sequence":"first","affiliation":[{"name":"Endocrine Research Center, Mashhad Medical University, Iran,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hale","family":"Rokni","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Mashhad Medical University, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedigheh","family":"Fatemi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Mashhad Medical University, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,1,24]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500363"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0273"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032061"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1210"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-52-2-231"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05844"}],"container-title":["Diabetes and Vascular Disease Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164110391917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1479164110391917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:21:27Z","timestamp":1777400487000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1479164110391917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1177\/1479164110391917"],"URL":"https:\/\/doi.org\/10.1177\/1479164110391917","relation":{},"ISSN":["1479-1641","1752-8984"],"issn-type":[{"value":"1479-1641","type":"print"},{"value":"1752-8984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}