{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:10:38Z","timestamp":1777558238509,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T00:00:00Z","timestamp":1318204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Objective: To identify the clinical parameters associated with increased carotid intima-media thickness (CIMT) in overweight and obese adolescents with type 2 diabetes.<\/jats:p>\n                  <jats:p>Methods: We studied 27 patients (11 males) with type 2 diabetes. Criteria for selection were age (12\u201319 years), body mass index above the 95th percentile for age and gender, a positive family history of diabetes, normal or high C-peptide, and negative studies for islet cell antibodies. Age- and gender-matched healthy subjects were selected as the control group. Measurements of CIMT, lipid profile, hypersensitive C-reactive protein, hemoglobin A1C (HbA1C), and insulin resistance by homeostasis model of assessment (HOMA) were obtained for all participants.<\/jats:p>\n                  <jats:p>Results: CIMT was higher in diabetic patients than in healthy subjects (0.68 \u00b1 0.16 vs. 0.58 \u00b1 0.1, p &lt; 0.01). The range of HbA1C in the 15 patients with uncontrolled diabetes was 7.6\u201310.4 (mean: 8.9 \u00b1 0.9). CIMT, HbA1C, systolic blood pressure, triglycerides, HOMA, and C-reactive protein were significantly higher in patients with uncontrolled than with controlled diabetes. In diabetic patients, CIMT correlated positively with body mass index ( p &lt; 0.001), duration of diabetes ( p &lt; 0.001), systolic ( p &lt; 0.001) and diastolic blood pressure ( p &lt; 0.01), HbA1C ( p &lt; 0.001), HOMA ( p &lt; 0.01), and C-reactive protein ( p &lt; 0.01).<\/jats:p>\n                  <jats:p>Conclusions: CIMT is increased in adolescents with type 2 diabetes. Poor glycemic control, HOMA, increased C-reactive protein, body mass index, duration of diabetes, and elevated blood pressure are associated with early atherosclerosis in these patients.<\/jats:p>","DOI":"10.1177\/1479164111421804","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T00:53:08Z","timestamp":1318294388000},"page":"35-41","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical and biochemical predictors of increased carotid intima-media thickness in overweight and obese adolescents with type 2 diabetes"],"prefix":"10.1177","volume":"9","author":[{"given":"Nesreen A","family":"Kotb","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania","family":"Gaber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Salama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala M","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdou","family":"Elhendy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Marshfield Clinic, Marshfield, WI, 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