{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:11:04Z","timestamp":1777558264954,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes and Vascular Disease Research"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study was designed to compare the efficacy and safety of a fenofibrate\/pravastatin 160\/40 mg fixed-dose combination plus ezetimibe 10 mg triple therapy and simvastatin 20 mg plus ezetimibe 10 mg dual therapy in patients with type 2 diabetes, mixed hyperlipidaemia and cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>After a 6-week run-in period on simvastatin 20 mg, 273 patients with non-high-density lipoprotein cholesterol (non-HDL-C) \u2265 100 mg\/dl or low-density lipoprotein cholesterol (LDL-C) \u2265 70 mg\/dl were randomised to receive 12-week treatment with triple therapy or dual therapy, followed by a 12-week safety period during which all patients received the triple therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At week 12, similar significant decreases in non-HDL-C were observed with both treatments. The triple therapy has induced a greater decrease in triglycerides (between-treatment difference: \u221214.6%, p = 0.007) and the dual therapy a greater decrease in LDL-C (between-treatment difference: +5.3%, p = 0.05). Both treatments were generally well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The fenofibrate\/pravastatin plus ezetimibe therapy improves the global atherogenic lipid profile in type 2 diabetic patients with mixed hyperlipidaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1479164111430715","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T21:47:52Z","timestamp":1325886472000},"page":"205-215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparative efficacy and safety of fenofibrate\/pravastatin plus ezetimibe triple therapy and simvastatin\/ezetimibe dual therapy in type 2 diabetic patients with mixed hyperlipidaemia and cardiovascular disease"],"prefix":"10.1177","volume":"9","author":[{"given":"Michel","family":"Farnier","sequence":"first","affiliation":[{"name":"Point M\u00e9dical, Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjetil","family":"Retterst\u00f8l","sequence":"additional","affiliation":[{"name":"Oslo University Hospital-Rikshospitalet, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Steinmetz","sequence":"additional","affiliation":[{"name":"St. Nikolaus-Stiftshospital GmbH, Teaching Hospital University of Bonn at Andernach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Cs\u00e1sz\u00e1r","sequence":"additional","affiliation":[{"name":"State Health Center, Budapest, 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